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Article Dans Une Revue Chemical Communications Année : 2014

First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors.

Résumé

The irreversible Michael addition of thiols to acrylamides is reported as a new tool for the kinetic target-guided synthesis. In an unprecedented enzymatic hydrolysis/thio-Michael addition procedure, potent and selective acetylcholinesterase inhibitors are assembled by the enzyme using both its esterasic and templating ability.

Domaines

Chimie organique
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Dates et versions

hal-00996567 , version 1 (26-05-2014)

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Emilia Oueis, Florian Nachon, Cyrille Sabot, Pierre-Yves Renard. First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors.. Chemical Communications, 2014, 50 (16), pp.2043-2045. ⟨10.1039/c3cc48871c⟩. ⟨hal-00996567⟩
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