Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels-Alder reaction of 5-alkoxyoxazoles with dienophiles. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2012

Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels-Alder reaction of 5-alkoxyoxazoles with dienophiles.

Résumé

A general and single-step access to polysubstituted 3-hydroxypyridine scaffolds via hetero-Diels-Alder (HDA) reactions between readily prepared 5-ethoxyoxazoles and dienophiles is reported. The HDA reaction, run in the presence of Nd(OTf)(3) at room temperature, was successfully applied to various 5-ethoxyoxazoles showing good functional group tolerance, and led to a straightforward process to obtain useful building-blocks.

Domaines

Chimie organique
Fichier non déposé

Dates et versions

hal-00996467 , version 1 (26-05-2014)

Identifiants

Citer

Cyrille Sabot, Emilia Oueis, Xavier Brune, Pierre-Yves Renard. Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels-Alder reaction of 5-alkoxyoxazoles with dienophiles.. Chemical Communications, 2012, 48 (5), pp.768-770. ⟨10.1039/c1cc16562c⟩. ⟨hal-00996467⟩
34 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More