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Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2010

Synthesis of pyrazolines by a site isolated resin-bound reagents methodology

Résumé

The elaboration of biologically important 3,4-substituted pyrazolines was achieved by an organocatalysed aza-Michael/transimination domino sequence between hydrazones and enones making use of a mixture of heterogeneous resin-bound acid/base reagents. This methodology nicely illustrates the site isolation concept of supported reagents allowing the simultaneous use of otherwise destructive reactive functionalities.

Domaines

Chimie organique

Dates et versions

hal-00992140 , version 1 (16-05-2014)

Identifiants

Citer

Vincent Gembus, Jean-Jacques Bonnet, François Janin, Pierre Bohn, Vincent Levacher, et al.. Synthesis of pyrazolines by a site isolated resin-bound reagents methodology. Organic & Biomolecular Chemistry, 2010, 8 (14), pp.3287-3293. ⟨10.1039/c004704j⟩. ⟨hal-00992140⟩
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