The Quito Fault System (QFS) extends over 60km along the Interandean Depression in northern Ecuador. Multidisciplinary studies support an interpretation in which two major contemporaneous fault systems affect Quaternary volcanoclastic deposits. Hanging paleovalleys and disruption of drainage networks attest to ongoing crustal deformation and uplift in this region, further confirmed by 15 years of GPS measurements and seismicity. The resulting new kinematic model emphasizes the role of the N-S segmented, en echelon eastward migrating Quito Fault System (QFS). Northeast of this major tectonic feature, the strike-slip Guayllabamba Fault System (GFS) aids the eastward transfer of the regional strain toward Colombia. These two tectonic fault systems are active, and the local focal mechanisms are consistent with the direction of relative GPS velocities and the regional stress tensor. Among active features, inherited N-S direction sutures appear to play a role in confining the active deformation in the Interandean Depression. The most frontal of the Quito faults formed at the tip of a blind thrust, dipping 40 degrees W, is most probably connected at depth to inactive suture to the west. A new GPS data set indicates active shortening rates for Quito blind thrust of up to 4mm/yr, which decreases northward along the fold system as it connects to the strike-slip Guayllabamba Fault System. The proximity of these structures to the densely populated Quito region highlights the need for additional tectonic studies in these regions of Ecuador to generate further hazard assessments.