Synthesis and cytotoxicity assay of four ganglioside GM3 analogues. - Archive ouverte HAL
Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2014

Synthesis and cytotoxicity assay of four ganglioside GM3 analogues.

Résumé

A concise and efficient synthetic route for preparation of four ganglioside GM3 analogues was described. The key step is a highly regioselective and stereoselective α-sialylation from a suitably protected glycoside acceptor with a sialyl xanthate to provide the sialo-oligosaccharide in good yield. The cytotoxic properties of the synthetic gangliosides were evaluated against normal human keratinocytes and human HCT116 and K562 cancer cells. Two of them exhibited good antiproliferative activity and displayed a better cytotoxicity against cancer cell than HaCaT normal cell.

Domaines

Chimie organique
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Dates et versions

hal-00986334 , version 1 (02-05-2014)

Identifiants

Citer

Huanhuan Qu, Jian-Miao Liu, Joanna Wdzieczak-Bakala, Dan Lu, Xianran He, et al.. Synthesis and cytotoxicity assay of four ganglioside GM3 analogues.. European Journal of Medicinal Chemistry, 2014, 75, pp.247-57. ⟨10.1016/j.ejmech.2014.01.054⟩. ⟨hal-00986334⟩
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