Structural basis for oligomerization of auxin transcriptional regulators. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2014

Structural basis for oligomerization of auxin transcriptional regulators.

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The plant hormone auxin is a key morphogenetic regulator acting from embryogenesis onwards. Transcriptional events in response to auxin are mediated by the auxin response factor (ARF) transcription factors and the Aux/IAA (IAA) transcriptional repressors. At low auxin concentrations, IAA repressors associate with ARF proteins and recruit corepressors that prevent auxin-induced gene expression. At higher auxin concentrations, IAAs are degraded and ARFs become free to regulate auxin-responsive genes. The interaction between ARFs and IAAs is thus central to auxin signalling and occurs through the highly conserved domain III/IV present in both types of proteins. Here, we report the crystal structure of ARF5 domain III/IV and reveal the molecular determinants of ARF-IAA interactions. We further provide evidence that ARFs have the potential to oligomerize, a property that could be important for gene regulation in response to auxin.
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hal-00984482 , version 1 (27-05-2020)

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Max H Nanao, Thomas Vinos-Poyo, Géraldine Brunoud, Emmanuel Thévenon, Meryl Mazzoleni, et al.. Structural basis for oligomerization of auxin transcriptional regulators.. Nature Communications, 2014, 5, pp.3617. ⟨10.1038/ncomms4617⟩. ⟨hal-00984482⟩
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