Unexpected high testis-specific transcriptional activity of the cyclin T1 promoter in transgenic mice. - Archive ouverte HAL
Article Dans Une Revue FEBS Letters Année : 2003

Unexpected high testis-specific transcriptional activity of the cyclin T1 promoter in transgenic mice.

Résumé

The ubiquitously expressed cyclin T1 gene encodes for a protein involved in human immunodeficiency virus type 1 (HIV-1) transcription activation. The goat gene was recently shown to share an expression pattern similar to that of its endogenous counterpart when incorporated into mice using a BAC insert. To assess if its promoter could target ubiquitous expression of the bovine Prnp in transgenic mice, two constructs carrying either 1 or 30 kb of cyclin T1 5'-flanking sequences were built and microinjected. Both constructs resulted in the unexpected high male germ cell-specific expression of the prion protein. These data re-question the suspected location of the cyclin T1 gene regulatory elements.
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Dates et versions

hal-00973817 , version 1 (04-04-2014)

Identifiants

  • HAL Id : hal-00973817 , version 1
  • PUBMED : 12914944

Citer

Xavier Mata, N. Besnard, K. Le Roux, G. Tilly, O. Andréoletti, et al.. Unexpected high testis-specific transcriptional activity of the cyclin T1 promoter in transgenic mice.. FEBS Letters, 2003, 549 (1-3), pp.163-6. ⟨hal-00973817⟩
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