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Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2013

Animals in a bacterial world, a new imperative for the life sciences.

Margaret Mcfall-Ngai
  • Function : Author
Michael G Hadfield
  • Function : Author
Thomas C G Bosch
  • Function : Author
Hannah V Carey
  • Function : Author
Tomislav Domazet-Lošo
  • Function : Author
Angela E Douglas
  • Function : Author
Gerard Eberl
Tadashi Fukami
  • Function : Author
Scott F Gilbert
  • Function : Author
Ute Hentschel
  • Function : Author
Nicole King
  • Function : Author
Staffan Kjelleberg
  • Function : Author
Andrew H Knoll
  • Function : Author
Sarkis K Mazmanian
  • Function : Author
Jessica L Metcalf
  • Function : Author
Kenneth Nealson
  • Function : Author
Naomi E Pierce
  • Function : Author
John F Rawls
  • Function : Author
Ann Reid
  • Function : Author
Edward G Ruby
  • Function : Author
Mary Rumpho
  • Function : Author
Jon G Sanders
  • Function : Author
Diethard Tautz
  • Function : Author
Jennifer J Wernegreen
  • Function : Author

Abstract

In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Specifically, we highlight recent technological and intellectual advances that have changed our thinking about five questions: how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other's genomes; how does normal animal development depend on bacterial partners; how is homeostasis maintained between animals and their symbionts; and how can ecological approaches deepen our understanding of the multiple levels of animal-bacterial interaction. As answers to these fundamental questions emerge, all biologists will be challenged to broaden their appreciation of these interactions and to include investigations of the relationships between and among bacteria and their animal partners as we seek a better understanding of the natural world.

Dates and versions

hal-00972300 , version 1 (03-04-2014)

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Margaret Mcfall-Ngai, Michael G Hadfield, Thomas C G Bosch, Hannah V Carey, Tomislav Domazet-Lošo, et al.. Animals in a bacterial world, a new imperative for the life sciences.. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (9), pp.3229-36. ⟨10.1073/pnas.1218525110⟩. ⟨hal-00972300⟩
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