Synthesis of cis-5-Trifluoromethylproline from L-Glutamic Acid - Archive ouverte HAL
Article Dans Une Revue SYNLETT Année : 2013

Synthesis of cis-5-Trifluoromethylproline from L-Glutamic Acid

Résumé

The diastereoselective synthesis of cis-5-trifluoromethylproline (5-Tfm-Pro) from l-glutamic acid is described. 5-Tfm-Pro could be obtained through a seven-step linear sequence. Trifluoromethylation of the glutamic-derived ester or aldehyde and subsequent reduction of the cyclic imine are the key steps in the synthesis.

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Chimie organique

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https://hal.science/hal-00969187

Soumis le : mercredi 2 avril 2014-11:06:36

Dernière modification le : lundi 15 juillet 2024-17:52:04

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hal-00969187 , version 1 (02-04-2014)

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Stéphanie Ortial, Rajesh Dave, Zohra Benfodda, David Bénimélis, Patrick Meffre. Synthesis of cis-5-Trifluoromethylproline from L-Glutamic Acid. SYNLETT, 2013, 2014 (25), pp.0569-0573. ⟨10.1055/s-0033-1340553⟩. ⟨hal-00969187⟩

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