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Article Dans Une Revue SYNLETT Année : 2013

Synthesis of cis-5-Trifluoromethylproline from L-Glutamic Acid

Résumé

The diastereoselective synthesis of cis-5-trifluoromethylproline (5-Tfm-Pro) from l-glutamic acid is described. 5-Tfm-Pro could be obtained through a seven-step linear sequence. Trifluoromethylation of the glutamic-derived ester or aldehyde and subsequent reduction of the cyclic imine are the key steps in the synthesis.
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Dates et versions

hal-00969187 , version 1 (02-04-2014)

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Stéphanie Ortial, Rajesh Dave, Zohra Benfodda, David Bénimélis, Patrick Meffre. Synthesis of cis-5-Trifluoromethylproline from L-Glutamic Acid. SYNLETT, 2013, 2014 (25), pp.0569-0573. ⟨10.1055/s-0033-1340553⟩. ⟨hal-00969187⟩
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