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Article Dans Une Revue Chemical Communications Année : 2013

Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to beta-lactams

G. Vadlamani
  • Fonction : Auteur
Paulo Rodrigues
A. Oliver
  • Fonction : Auteur
B.L. Mark
  • Fonction : Auteur
D.J. Vocadlo
  • Fonction : Auteur
  • PersonId : 954601
Y. Blériot

Résumé

AmpC beta-lactamase confers resistance to b-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to beta-lactams.

Dates et versions

hal-00968733 , version 1 (01-04-2014)

Identifiants

Citer

M. Mondon, S. Hur, G. Vadlamani, Paulo Rodrigues, P. Tsybina, et al.. Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to beta-lactams. Chemical Communications, 2013, 49 (93), pp.10983-10985. ⟨10.1039/c3cc46646a⟩. ⟨hal-00968733⟩
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