Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Année : 2014

Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila.

Nathalie Arquier
Julie Kniazeff
Jean-Philippe Pin

Résumé

The brain is the central organizer of food intake, matching the quality and quantity of the food sources with organismal needs. To ensure appropriate amino acid balance, many species reject a diet lacking one or several essential amino acids (EAAs) and seek out a better food source. Here, we show that, in Drosophila larvae, this behavior relies on innate sensing of amino acids in dopaminergic (DA) neurons of the brain. We demonstrate that the amino acid sensor GCN2 acts upstream of GABA signaling in DA neurons to promote avoidance of the EAA-deficient diet. Using real-time calcium imaging in larval brains, we show that amino acid imbalance induces a rapid and reversible activation of three DA neurons that are necessary and sufficient for food rejection. Taken together, these data identify a central amino-acid-sensing mechanism operating in specific DA neurons and controlling food intake.

Dates et versions

hal-00968719 , version 1 (01-04-2014)

Identifiants

Citer

Marianne Bjordal, Nathalie Arquier, Julie Kniazeff, Jean-Philippe Pin, Pierre Léopold. Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila.. Cell, 2014, 156 (3), pp.510-21. ⟨10.1016/j.cell.2013.12.024⟩. ⟨hal-00968719⟩
50 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More