Theoretical study of the basic mechanisms of DNA damage by therapeutic radiation beams - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2014

Theoretical study of the basic mechanisms of DNA damage by therapeutic radiation beams

Résumé

Cancer treatments by photon radiation beams in radiotherapy is currently grounded on a rather empirical understanding of the basic mechanisms of DNA damages. It is well assessed that radiation induces single-strand and double-strand breaks in DNA, being however the various mechanisms largely unknown. Conversely, the mechanical behaviour of undamaged DNA is today well understood, both experimentally and theoretically [1]. Thanks to an ad-hoc developed Silicon Nanotweezer (SNT) [2], we can perform direct measurements of the mechanical response of DNA bundles under irradiation. This allows to measure, with high precision, the rate of breaking of DNA as a function of the various external agents. Grounded in our previous developments in polymer physics [3, 4], a theoretical investigation of DNA damage has been introduced to complement experiments. We formulate analytical models and perform Monte Carlo simulations, to quantitatively evaluate the visco-elastic response for DNA bundles, which experience breaks induced by a photon radiation beam. The numerical simulations confirm the analytical achievements and allow to study situations closely representing the experimental conditions. [1] C. R. Calladine et al., Understanding DNA: The Molecule and How It Works (Elsevier Academic Press, Amsterdam, 2004). [2] C. Yamahata et al., JMEMS 17, no. 3 (2008) 623. [3] F. Manca et al,. J. Chem. Phys. 136 (2012) 154906. [4] F. Manca et al., Phys. Rev. E 87 (2013) 032705.
Fichier non déposé

Dates et versions

hal-00966158 , version 1 (26-03-2014)

Identifiants

  • HAL Id : hal-00966158 , version 1

Citer

F. Manca, Stefano Giordano, Pier Luca Palla, Grégoire Perret, E. Lartigau, et al.. Theoretical study of the basic mechanisms of DNA damage by therapeutic radiation beams. European Materials Research Society Spring Meeting, E-MRS Spring 2014, Symposium N - Converging technology for nanobio-applications, 2014, Lille, France. ⟨hal-00966158⟩
95 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More