Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.
Jessica Becker
,
Darina Czamara
(1)
,
Tom S Scerri
,
Franck Ramus
(2)
,
Valéria Csépe
,
Joel B Talcott
,
John Stein
,
Andrew Morris
(3)
,
Kerstin U Ludwig
,
Per Hoffmann
(4)
,
Ferenc Honbolygó
,
Dénes Tóth
,
Fabien Fauchereau
(5)
,
Caroline Bogliotti
(6)
,
Stéphanie Iannuzzi
,
Yves Chaix
(7)
,
Sylviane Valdois
(8)
,
Catherine Billard
(9)
,
Florence George
(10)
,
Isabelle Soares-Boucaud
,
Christophe-Loïc Gérard
,
Sanne van Der Mark
,
Enrico Schulz
,
Anniek Vaessen
,
Urs Maurer
,
Kaisa Lohvansuu
,
Heikki Lyytinen
,
Marco Zucchelli
,
Daniel Brandeis
,
Leo Blomert
,
Paavo Ht Leppänen
,
Jennifer Bruder
,
Anthony P Monaco
(11)
,
Bertram Müller-Myhsok
(4)
,
Juha Kere
(12, 13)
,
Karin Landerl
,
Markus M Nöthen
(14)
,
Gerd Schulte-Körne
(15)
,
Silvia Paracchini
,
Myriam Peyrard-Janvid
,
Johannes Schumacher
(16)
1
Max-Planck-Institut für Psychiatrie
2 LSCP - Laboratoire de sciences cognitives et psycholinguistique
3 MI - Mathematical Institute [Oxford]
4 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
5 Génétique Humaine et Fonctions Cognitives
6 MoDyCo - Modèles, Dynamiques, Corpus
7 ICHN - Imagerie cérébrale et handicaps neurologiques
8 LPNC - Laboratoire de Psychologie et NeuroCognition
9 C3ED - Centre d'économie et d'éthique pour l'environnement et le développement
10 LPC - Laboratoire de psychologie cognitive
11 The Wellcome Trust Centre for Human Genetics [Oxford]
12 Department of Biosciences and Nutrition
13 Clinical Research Centre
14 Institute of Human Genetics
15 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
16 Institute of Human Genetics
2 LSCP - Laboratoire de sciences cognitives et psycholinguistique
3 MI - Mathematical Institute [Oxford]
4 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
5 Génétique Humaine et Fonctions Cognitives
6 MoDyCo - Modèles, Dynamiques, Corpus
7 ICHN - Imagerie cérébrale et handicaps neurologiques
8 LPNC - Laboratoire de Psychologie et NeuroCognition
9 C3ED - Centre d'économie et d'éthique pour l'environnement et le développement
10 LPC - Laboratoire de psychologie cognitive
11 The Wellcome Trust Centre for Human Genetics [Oxford]
12 Department of Biosciences and Nutrition
13 Clinical Research Centre
14 Institute of Human Genetics
15 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy
16 Institute of Human Genetics
Jessica Becker
- Function : Author
Darina Czamara
- Function : Author
- PersonId : 764411
- ORCID : 0000-0001-7381-904X
Tom S Scerri
- Function : Author
Franck Ramus
- Function : Author
- PersonId : 117
- IdHAL : franck-ramus
- ORCID : 0000-0002-1122-5913
- IdRef : 071517383
Valéria Csépe
- Function : Author
Joel B Talcott
- Function : Author
John Stein
- Function : Author
Kerstin U Ludwig
- Function : Author
Ferenc Honbolygó
- Function : Author
Dénes Tóth
- Function : Author
Caroline Bogliotti
- Function : Author
- PersonId : 1027944
- IdHAL : carolinebogliotti
- ORCID : 0000-0003-1413-1135
Stéphanie Iannuzzi
- Function : Author
Yves Chaix
- Function : Author
- PersonId : 948824
- IdRef : 056706464
Sylviane Valdois
- Function : Author
- PersonId : 753469
- IdHAL : sylviane-valdois
- ORCID : 0000-0002-4562-7267
- IdRef : 05953091X
Isabelle Soares-Boucaud
- Function : Author
Christophe-Loïc Gérard
- Function : Author
Sanne van Der Mark
- Function : Author
Enrico Schulz
- Function : Author
Anniek Vaessen
- Function : Author
Urs Maurer
- Function : Author
Kaisa Lohvansuu
- Function : Author
Heikki Lyytinen
- Function : Author
Marco Zucchelli
- Function : Author
Daniel Brandeis
- Function : Author
Leo Blomert
- Function : Author
Paavo Ht Leppänen
- Function : Author
Jennifer Bruder
- Function : Author
Bertram Müller-Myhsok
- Function : Author
- PersonId : 763103
- ORCID : 0000-0002-0719-101X
- IdRef : 152975233
Karin Landerl
- Function : Author
Silvia Paracchini
- Function : Author
Myriam Peyrard-Janvid
- Function : Author
Abstract
: Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from understanding the molecular mechanisms leading to the disorder. Several candidate genes have been implicated in dyslexia, including DYX1C1, DCDC2, KIAA0319, and the MRPL19/C2ORF3 locus, each with reports of both positive and no replications. We generated a European cross-linguistic sample of school-age children - the NeuroDys cohort - that includes more than 900 individuals with dyslexia, sampled with homogenous inclusion criteria across eight European countries, and a comparable number of controls. Here, we describe association analysis of the dyslexia candidate genes/locus in the NeuroDys cohort. We performed both case-control and quantitative association analyses of single markers and haplotypes previously reported to be dyslexia-associated. Although we observed association signals in samples from single countries, we did not find any marker or haplotype that was significantly associated with either case-control status or quantitative measurements of word-reading or spelling in the meta-analysis of all eight countries combined. Like in other neurocognitive disorders, our findings underline the need for larger sample sizes to validate possibly weak genetic effects.European Journal of Human Genetics advance online publication, 11 September 2013; doi:10.1038/ejhg.2013.199.