Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate. - Archive ouverte HAL Access content directly
Journal Articles Pathology - Research and Practice Year : 1994

Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate.

Abstract

Interferon-gamma is a T cell secreted cytokine. It has a great number of biological activities, among which is the down regulation of collagen molecules. IFN-gamma acts through cell surface receptors, but also binds to heparan sulfate proteoglycans. In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine.

Dates and versions

hal-00955800 , version 1 (05-03-2014)

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H. Lortat-Jacob, P. Esterre, J. A. Grimaud. Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate.. Pathology - Research and Practice, 1994, 190 (9-10), pp.920-2. ⟨10.1016/S0344-0338(11)80996-9⟩. ⟨hal-00955800⟩

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