<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00955786</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T09:46:50+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Interferon-gamma C-terminal function: new working hypothesis. Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity.</title>
            <author role="aut">
              <persName>
                <forename type="first">H.</forename>
                <surname>Lortat-Jacob</surname>
              </persName>
              <idno type="halauthorid">186541-0</idno>
              <affiliation ref="#struct-246259"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J. A.</forename>
                <surname>Grimaud</surname>
              </persName>
              <idno type="halauthorid">310690-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Hugues</forename>
                <surname>Lortat-Jacob</surname>
              </persName>
              <email type="md5">a9f7ea1b8af4fbd1683ea1a2c9668d1a</email>
              <email type="domain">ibs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2014-03-05 11:47:11</date>
              <date type="whenModified">2024-12-19 11:12:04</date>
              <date type="whenReleased">2014-03-05 11:47:11</date>
              <date type="whenProduced">1991</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="122657">
                <persName>
                  <forename>Hugues</forename>
                  <surname>Lortat-Jacob</surname>
                </persName>
                <email type="md5">a9f7ea1b8af4fbd1683ea1a2c9668d1a</email>
                <email type="domain">ibs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00955786</idno>
            <idno type="halUri">https://hal.science/hal-00955786</idno>
            <idno type="halBibtex">lortatjacob:hal-00955786</idno>
            <idno type="halRefHtml">&lt;i&gt;Cellular and Molecular Biology&lt;/i&gt;, 1991, 37 (3), pp.253-60</idno>
            <idno type="halRef">Cellular and Molecular Biology, 1991, 37 (3), pp.253-60</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="RIIP">Pasteur Network</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Interferon-gamma C-terminal function: new working hypothesis. Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">H.</forename>
                    <surname>Lortat-Jacob</surname>
                  </persName>
                  <idno type="halauthorid">186541-0</idno>
                  <affiliation ref="#struct-246259"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J. A.</forename>
                    <surname>Grimaud</surname>
                  </persName>
                  <idno type="halauthorid">310690-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22490</idno>
                <idno type="issn">0145-5680</idno>
                <idno type="eissn">1165-158X</idno>
                <title level="j">Cellular and Molecular Biology</title>
                <imprint>
                  <publisher>CMB Association</publisher>
                  <biblScope unit="volume">37</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">253-60</biblScope>
                  <date type="datePub">1991</date>
                </imprint>
              </monogr>
              <idno type="pubmed">1934005</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Amino Acid Sequence</classCode>
              <classCode scheme="mesh">Heparin</classCode>
              <classCode scheme="mesh">Heparitin Sulfate</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Interferon-gamma</classCode>
              <classCode scheme="mesh">Molecular Sequence Data</classCode>
              <classCode scheme="mesh">Structure-Activity Relationship</classCode>
              <classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Structure and function of the interferon-gamma C-terminal extremity has been widely studied. A basic amino acid cluster located in this domain is involved in the tridimentional structure of the protein and is essential for the biological activity. This specific group of amino acid is also involved in the binding of interferon-gamma to basement membrane or cell surface heparan sulfate. Once bound to heparan sulfate, interferon-gamma is protected from proteolytic cleavage and it is suggested that the protein folds in a new relaxed conformation, with increased stability.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-246259" status="OLD">
          <orgName>Institut Pasteur de Lyon</orgName>
          <desc>
            <address>
              <addrLine>Lyon, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-301247" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301247" status="VALID">
          <orgName>Pasteur Network (Réseau International des Instituts Pasteur)</orgName>
          <desc>
            <address>
              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://pasteur-network.org/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>