Efficient biocatalytic processes for highly valuable terminally phosphorylated C5 to C9 D-ketoses. - Archive ouverte HAL
Article Dans Une Revue Green Chemistry Année : 2014

Efficient biocatalytic processes for highly valuable terminally phosphorylated C5 to C9 D-ketoses.

Résumé

A green enzymatic strategy for the synthesis of terminally phosphorylated C5 to C9 naturally occurring D-ketose phosphates and analogues was developed using D-fructose-6-phosphate aldolase (FSA) as a catalyst. This enzyme has stereoselectively catalysed aldol reactions between glycolaldehyde phosphate or ribose-5-phosphate as an acceptor substrate and dihydroxyacetone, hydroxyacetone or hydroxybutanone as a donor. Furthermore, D-glycero-D-altro-2-octulose 8-phosphate was obtained using a straightforward one-pot domino biocatalytic system involving FSA, ribulose-5-phosphate epimerase and ribose-5-phosphate isomerase controlling five contiguous asymmetric centres and starting from achiral material.
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Dates et versions

hal-00952616 , version 1 (27-02-2014)

Identifiants

  • HAL Id : hal-00952616 , version 1

Citer

Christine Guérard-Hélaine, M. Debacker, P. Clapés, A. Szekrenyi, V. Hélaine, et al.. Efficient biocatalytic processes for highly valuable terminally phosphorylated C5 to C9 D-ketoses.. Green Chemistry, 2014, 16, pp.1109-1113. ⟨hal-00952616⟩
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