From Diketopiperazines to Hydantoins: An Unprecedented Rearrangement - Archive ouverte HAL
Article Dans Une Revue SYNLETT Année : 2014

From Diketopiperazines to Hydantoins: An Unprecedented Rearrangement

Résumé

Bis-Boc-activated 2,5-diketopiperazines on reaction with potassium hydroxide or sodium methoxide in dry tetrahydrofuran led to Boc-protected hydantoins through an unprecedented ring contraction. This rearrangement was applied to several monosubstituted 2,5-diketopiperazines with good yields and regioselectivity.
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Dates et versions

hal-00951723 , version 1 (25-02-2014)

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Guilhem Chaubet, Guillaume Cazals, Aurélien Lebrun, Jean Martinez, Isabelle Parrot. From Diketopiperazines to Hydantoins: An Unprecedented Rearrangement. SYNLETT, 2014, 25 (4), pp.574-578. ⟨10.1055/s-0033-1340622⟩. ⟨hal-00951723⟩
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