Gold nanorods with phase-changing polymer corona for remotely near-infrared-triggered drug release. - Archive ouverte HAL Access content directly
Journal Articles Chemistry - An Asian Journal Year : 2014

Gold nanorods with phase-changing polymer corona for remotely near-infrared-triggered drug release.

Abstract

Herein, we report a new drug-delivery system (DDS) that is comprised of a near-infrared (NIR)-light-sensitive gold-nanorod (GNR) core and a phase-changing poly(ε-caprolactone)-b-poly(ethylene glycol) polymer corona (GNR@PCL-b-PEG). The underlying mechanism of the drug-loading and triggered-release behaviors involves the entrapment of drug payloads among the PCL crystallites and a heat-induced phase change, respectively. A low premature release of the pre-loaded doxorubicin was observed in PBS buffer (pH 7.4) at 37 °C (<10% of the entire payload after 48 h). However, release could be activated within 30 min by conventional heating at 50 °C, above the Tm of the crystalline PCL domain (43.5 °C), with about 60% release over the subsequent 42 h at 37 °C. The NIR-induced heating of an aqueous suspension of GNR@PCL-b-PEG under NIR irradiation (802 nm) was investigated in terms of the irradiation period, power, and concentration-dependent heating behavior, as well as the NIR-induced shape-transformation of the GNR cores. Remotely NIR-triggered release was also explored upon NIR irradiation for 30 min and about 70% release was achieved in the following 42 h at 37 °C, with a mild warming (<4 °C) of the surroundings. The cytotoxicity of GNR@PCL-b-PEG against the mouse fibroblastic-like L929 cell-line was assessed by MTS assay and good compatibility was confirmed with a cell viability of over 90% after incubation for 72 h. The cellular uptake of GNR@PCL-b-PEG by melanoma MEL-5 cells was also confirmed, with an averaged uptake of 1250(±110) particles cell(-1) after incubation for 12 h (50 μg mL(-1)). This GNR@PCL-b-PEG DDS is aimed at addressing the different requirements for therapeutic treatments and is envisaged to provide new insights into DDS targeting for remotely triggered release by NIR activation.

Dates and versions

hal-00949267 , version 1 (19-02-2014)

Identifiers

Cite

Ji Liu, Christophe Detrembleur, Bruno Grignard, Marie-Claire de Pauw-Gillet, Stéphane Mornet, et al.. Gold nanorods with phase-changing polymer corona for remotely near-infrared-triggered drug release.. Chemistry - An Asian Journal, 2014, 9 (1), pp.275-288. ⟨10.1002/asia.201301010⟩. ⟨hal-00949267⟩
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