<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00949166</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T01:55:06+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation.</title>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Spierings</surname>
              </persName>
              <idno type="halauthorid">804286-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yeung-Hyen</forename>
                <surname>Kim</surname>
              </persName>
              <idno type="halauthorid">804287-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Matthijs</forename>
                <surname>Hendriks</surname>
              </persName>
              <idno type="halauthorid">804288-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Borst</surname>
              </persName>
              <idno type="halauthorid">804289-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ruhena</forename>
                <surname>Sergeant</surname>
              </persName>
              <idno type="halauthorid">804290-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Angelica</forename>
                <surname>Canossi</surname>
              </persName>
              <idno type="halauthorid">804291-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Machteld</forename>
                <surname>Oudshoorn</surname>
              </persName>
              <idno type="halauthorid">804292-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pascale</forename>
                <surname>Loiseau</surname>
              </persName>
              <idno type="halauthorid">252146-0</idno>
              <affiliation ref="#struct-93257"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Harry</forename>
                <surname>Dolstra</surname>
              </persName>
              <idno type="halauthorid">631842-0</idno>
              <affiliation ref="#struct-190529"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Miroslaw</forename>
                <surname>Markiewicz</surname>
              </persName>
              <idno type="halauthorid">804293-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mary S</forename>
                <surname>Leffell</surname>
              </persName>
              <idno type="halauthorid">804294-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Noemi</forename>
                <surname>Pereira</surname>
              </persName>
              <idno type="halauthorid">804295-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Brigitte</forename>
                <surname>Kircher</surname>
              </persName>
              <idno type="halauthorid">804296-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hannu</forename>
                <surname>Turpeinen</surname>
              </persName>
              <idno type="halauthorid">804297-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-François</forename>
                <surname>Eliaou</surname>
              </persName>
              <idno type="halauthorid">598643-0</idno>
              <affiliation ref="#struct-174983"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thibaut</forename>
                <surname>Gervais</surname>
              </persName>
              <idno type="halauthorid">804298-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Laurin</surname>
              </persName>
              <email type="md5">e138aa9217d2586f1419602ecd9bebf8</email>
              <email type="domain">efs.sante.fr</email>
              <idno type="idhal" notation="string">david-laurin</idno>
              <idno type="idhal" notation="numeric">1200358</idno>
              <idno type="halauthorid" notation="string">464687-1200358</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9339-8369</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-7895-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-7895-2014</idno>
              <affiliation ref="#struct-388270"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jürgen</forename>
                <surname>Enczmann</surname>
              </persName>
              <idno type="halauthorid">804299-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Miryam</forename>
                <surname>Martinetti</surname>
              </persName>
              <idno type="halauthorid">408502-0</idno>
              <affiliation ref="#struct-303140"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jackie</forename>
                <surname>Thomson</surname>
              </persName>
              <idno type="halauthorid">769233-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fatma</forename>
                <surname>Oguz</surname>
              </persName>
              <idno type="halauthorid">804300-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stella</forename>
                <surname>Santarone</surname>
              </persName>
              <idno type="halauthorid">726026-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jukka</forename>
                <surname>Partanen</surname>
              </persName>
              <idno type="halauthorid">521562-0</idno>
              <affiliation ref="#struct-138476"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Urszula</forename>
                <surname>Siekiera</surname>
              </persName>
              <idno type="halauthorid">804301-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emilio Paolo</forename>
                <surname>Alessandrino</surname>
              </persName>
              <idno type="halauthorid">804302-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sevgi</forename>
                <surname>Kalayoglu</surname>
              </persName>
              <idno type="halauthorid">804303-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ronald</forename>
                <surname>Brand</surname>
              </persName>
              <idno type="halauthorid">464749-0</idno>
              <affiliation ref="#struct-138291"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Els</forename>
                <surname>Goulmy</surname>
              </persName>
              <idno type="halauthorid">804304-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Marie-Claire</forename>
                <surname>Dagher</surname>
              </persName>
              <email type="md5">16a92a66fdebde7a6e37680303039cc5</email>
              <email type="domain">ibs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2014-02-19 11:22:19</date>
              <date type="whenModified">2025-12-17 08:18:03</date>
              <date type="whenReleased">2014-02-19 11:22:19</date>
              <date type="whenProduced">2013-08</date>
              <ref type="externalLink" target="http://www.astctjournal.org/article/S1083879113002358/pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="140374">
                <persName>
                  <forename>Marie-Claire</forename>
                  <surname>Dagher</surname>
                </persName>
                <email type="md5">16a92a66fdebde7a6e37680303039cc5</email>
                <email type="domain">ibs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00949166</idno>
            <idno type="halUri">https://hal.science/hal-00949166</idno>
            <idno type="halBibtex">spierings:hal-00949166</idno>
            <idno type="halRefHtml">&lt;i&gt;Biology of Blood and Marrow Transplantation&lt;/i&gt;, 2013, 19 (8), pp.1244-53. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.bbmt.2013.06.001"&gt;&amp;#x27E8;10.1016/j.bbmt.2013.06.001&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Biology of Blood and Marrow Transplantation, 2013, 19 (8), pp.1244-53. &amp;#x27E8;10.1016/j.bbmt.2013.06.001&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-THEREX" corresp="TIMC-IMAG">TheREx : Thérapeutique Recombinante Expérimentale</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Spierings</surname>
                  </persName>
                  <idno type="halauthorid">804286-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yeung-Hyen</forename>
                    <surname>Kim</surname>
                  </persName>
                  <idno type="halauthorid">804287-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Matthijs</forename>
                    <surname>Hendriks</surname>
                  </persName>
                  <idno type="halauthorid">804288-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Borst</surname>
                  </persName>
                  <idno type="halauthorid">804289-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ruhena</forename>
                    <surname>Sergeant</surname>
                  </persName>
                  <idno type="halauthorid">804290-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Angelica</forename>
                    <surname>Canossi</surname>
                  </persName>
                  <idno type="halauthorid">804291-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Machteld</forename>
                    <surname>Oudshoorn</surname>
                  </persName>
                  <idno type="halauthorid">804292-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pascale</forename>
                    <surname>Loiseau</surname>
                  </persName>
                  <idno type="halauthorid">252146-0</idno>
                  <affiliation ref="#struct-93257"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Harry</forename>
                    <surname>Dolstra</surname>
                  </persName>
                  <idno type="halauthorid">631842-0</idno>
                  <affiliation ref="#struct-190529"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Miroslaw</forename>
                    <surname>Markiewicz</surname>
                  </persName>
                  <idno type="halauthorid">804293-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mary S</forename>
                    <surname>Leffell</surname>
                  </persName>
                  <idno type="halauthorid">804294-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Noemi</forename>
                    <surname>Pereira</surname>
                  </persName>
                  <idno type="halauthorid">804295-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Brigitte</forename>
                    <surname>Kircher</surname>
                  </persName>
                  <idno type="halauthorid">804296-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hannu</forename>
                    <surname>Turpeinen</surname>
                  </persName>
                  <idno type="halauthorid">804297-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-François</forename>
                    <surname>Eliaou</surname>
                  </persName>
                  <idno type="halauthorid">598643-0</idno>
                  <affiliation ref="#struct-174983"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thibaut</forename>
                    <surname>Gervais</surname>
                  </persName>
                  <idno type="halauthorid">804298-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Laurin</surname>
                  </persName>
                  <email type="md5">e138aa9217d2586f1419602ecd9bebf8</email>
                  <email type="domain">efs.sante.fr</email>
                  <idno type="idhal" notation="string">david-laurin</idno>
                  <idno type="idhal" notation="numeric">1200358</idno>
                  <idno type="halauthorid" notation="string">464687-1200358</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9339-8369</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-7895-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-7895-2014</idno>
                  <affiliation ref="#struct-388270"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jürgen</forename>
                    <surname>Enczmann</surname>
                  </persName>
                  <idno type="halauthorid">804299-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Miryam</forename>
                    <surname>Martinetti</surname>
                  </persName>
                  <idno type="halauthorid">408502-0</idno>
                  <affiliation ref="#struct-303140"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jackie</forename>
                    <surname>Thomson</surname>
                  </persName>
                  <idno type="halauthorid">769233-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fatma</forename>
                    <surname>Oguz</surname>
                  </persName>
                  <idno type="halauthorid">804300-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stella</forename>
                    <surname>Santarone</surname>
                  </persName>
                  <idno type="halauthorid">726026-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jukka</forename>
                    <surname>Partanen</surname>
                  </persName>
                  <idno type="halauthorid">521562-0</idno>
                  <affiliation ref="#struct-138476"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Urszula</forename>
                    <surname>Siekiera</surname>
                  </persName>
                  <idno type="halauthorid">804301-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emilio Paolo</forename>
                    <surname>Alessandrino</surname>
                  </persName>
                  <idno type="halauthorid">804302-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sevgi</forename>
                    <surname>Kalayoglu</surname>
                  </persName>
                  <idno type="halauthorid">804303-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ronald</forename>
                    <surname>Brand</surname>
                  </persName>
                  <idno type="halauthorid">464749-0</idno>
                  <affiliation ref="#struct-138291"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Els</forename>
                    <surname>Goulmy</surname>
                  </persName>
                  <idno type="halauthorid">804304-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11177</idno>
                <idno type="issn">1083-8791</idno>
                <idno type="eissn">1523-6536</idno>
                <title level="j">Biology of Blood and Marrow Transplantation</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">19</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">1244-53</biblScope>
                  <date type="datePub">2013-08</date>
                  <date type="dateEpub">2013-06-10</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.bbmt.2013.06.001</idno>
              <idno type="pubmed">23756210</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.imm.ii">Life Sciences [q-bio]/Immunology/Innate immunity</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The effect of minor H antigen mismatching on the occurrence of graft-versus-host disease (GvHD) and graft-versus-leukemia (GvL) after HLA-matched hematopoietic stem cell transplantation (HSCT) has mainly been demonstrated in single-center studies. Yet, the International Histocompatibility and Immunogenetics Workshops (IHIW) provide a collaborative platform to execute crucial large studies. In collaboration with 20 laboratories of the IHIW, the roles of 10 autosomal and 10 Y chromosome-encoded minor H antigens were investigated on GvHD and relapse incidence in 639 HLA-identical related donor (IRD) and 210 HLA-matched unrelated donor (MUD) HSCT recipients. Donor and recipient DNA samples were genotyped for the minor H antigens HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1, ACC-2, SP110, PANE1, UGT2B17, and HY. The correlations with the primary outcomes GvHD (acute or chronic GvHD), survival, and relapse were statistically analyzed. The results of these multicenter analyses show that none of the HLA class I-restricted HY antigens were found to be associated with any of the primary outcomes. Interestingly, of the HLA class II-restricted HY antigens analyzed, HLA-DQ5 positive recipients showed a significantly increased GvHD-free survival in female-to-male HSCT compared with male-to-female HSCT (P = .013). Yet, analysis of the overall gender effect, thus independent of the known HY antigens, between the gender groups demonstrated an increased GvHD incidence in the female-to-male transplantations (P &lt; .005) and a decreased GvHD-free survival in the female-to-male transplantations (P &lt; .001). Of all autosomally encoded minor H antigens, only mismatching for the broadly expressed minor H antigen HA-8 increased the GvHD incidence in IRD HSCT (Hazard ratio [HR] = 5.28, P &lt; .005), but not in MUD HSCT. Most striking was the influence of hematopoietic restricted minor H antigens on GvL as mismatching for hematopoietic minor H antigens correlated with lower relapse rates (P = .078), higher relapse-free survival (P = .029), and higher overall survival (P = .032) in recipients with GvHD, but not in those without GvHD. In conclusion, the significant GvHD effect of the broadly expressed minor H antigen HA-8 favors matching for HA-8 in IRD, but not in MUD, patient/donor pairs. The GvHD-GvL association demonstrating a significant lower relapse in hematopoietic minor H antigen mismatched patient/donor pairs underlines their clinical applicability for adoptive immunotherapy, enhancing the GvL effect in a GvHD controllable manner.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-93257" status="OLD">
          <orgName>Immunogénétique humaine</orgName>
          <desc>
            <address>
              <addrLine>Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation name="E021 / U396" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-190529" status="INCOMING">
          <orgName>Department of Laboratory Medicine</orgName>
          <desc>
            <address>
              <addrLine>Nijmegen</addrLine>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300856" type="direct"/>
            <relation active="#struct-324669" type="direct"/>
            <relation active="#struct-347499" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-174983" status="INCOMING">
          <orgName>Laboratoire d'Immunologie</orgName>
          <desc>
            <address>
              <addrLine>Montpellier</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-303483" type="direct"/>
            <relation active="#struct-258773" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388270" status="INCOMING">
          <orgName>TheREx</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303140" status="VALID">
          <idno type="IdRef">026430703</idno>
          <idno type="ISNI">0000000417625736</idno>
          <idno type="ROR">https://ror.org/00s6t1f81</idno>
          <idno type="Wikidata">Q219317</idno>
          <orgName>Università degli Studi di Pavia [Italia] = University of Pavia [Italy] = Université de Pavie [Italie]</orgName>
          <orgName type="acronym">UNIPV</orgName>
          <date type="start">1361-01-01</date>
          <desc>
            <address>
              <addrLine>Corso Strada Nuova, 65 - Pavie</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">http://www.unipv.eu/site/en/home.html</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-138476" status="INCOMING">
          <orgName>Department of Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service</orgName>
          <desc>
            <address>
              <country key="FI"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-333875" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-138291" status="INCOMING">
          <orgName>Department of neurology</orgName>
          <desc>
            <address>
              <addrLine>P.O. Box 9600, Albinusdreef 2, 2300 RC Leiden</addrLine>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300851" type="direct"/>
            <relation active="#struct-121723" type="indirect"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300856" status="VALID">
          <idno type="IdRef">112681611</idno>
          <idno type="ROR">https://ror.org/016xsfp80</idno>
          <orgName>Radboud University [Nijmegen]</orgName>
          <desc>
            <address>
              <addrLine>Houtlaan 4, 6525 XZ Nijmegen</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.ru.nl/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-324669" status="INCOMING">
          <orgName>Nijmegen Centre for Molecular Life Sciences</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-347499" status="VALID">
          <orgName>Nijmegen Medical Centre [Nijmegen]</orgName>
          <desc>
            <address>
              <addrLine>Geert Grooteplein Zuid 6525, 6525 GA Nijmegen</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.radboudumc.nl/reshape</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303483" status="VALID">
          <idno type="ROR">https://ror.org/04pwyfk22</idno>
          <orgName>Hôpital Saint Eloi [CHU Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>80 avenue Augustin Fliche - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/a-propos-du-chu/decouvrir/etablissements/saint-eloi</ref>
          </desc>
          <listRelation>
            <relation active="#struct-258773" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-258773" status="VALID">
          <idno type="ISNI">000000009961060X</idno>
          <idno type="ROR">https://ror.org/04m6sq715</idno>
          <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
          <orgName type="acronym">CHRU Montpellier</orgName>
          <desc>
            <address>
              <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-333875" status="INCOMING">
          <orgName>Department of Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300851" status="VALID">
          <idno type="ROR">https://ror.org/05xvt9f17</idno>
          <orgName>Leiden University Medical Center [Leiden]</orgName>
          <orgName type="acronym">LUMC</orgName>
          <desc>
            <address>
              <addrLine>Leids Universitair Medisch Centrum, Universiteit Leiden - 1233 ZA, Leiden</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.lumc.nl</ref>
          </desc>
          <listRelation>
            <relation active="#struct-121723" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-121723" status="VALID">
          <idno type="ROR">https://ror.org/027bh9e22</idno>
          <orgName>Universiteit Leiden = Leiden University</orgName>
          <desc>
            <address>
              <addrLine>Leiden University | 2300 RA Leiden The Netherlands</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.universiteitleiden.nl/en/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>