Epithelial mucins and bacterial adhesion - Archive ouverte HAL Accéder directement au contenu
Chapitre D'ouvrage Année : 2014

Epithelial mucins and bacterial adhesion

Résumé

Mucins are high molecular weight glycoproteins characterized by highly O-glycosylated tandem repeat domains. Mucin-type O-glycans exhibit a variety of terminal sequences including histo-blood group antigens that serve as counter receptors and participate to in the adhesion and clearance of numerous bacteria including pathogens. In parallel, the pathological changes of mucin glycosylation modulate bacterial adhesion, often enhancing the adhesion of pathogenic bacteria. This review summarizes the current knowledge on the structure and biosynthesis of epithelial mucin O-glycans chains, the physio-pathological glycosylation repertoire of mucins and the role of mucin glycosylation in bacterial adhesion, focusing on the gastrointestinal tract and airway mucins.

Dates et versions

hal-00949086 , version 1 (19-02-2014)

Identifiants

Citer

Florent Colomb, Catherine Robbe-Masselot, Sophie Groux-Degroote, Julie Bouckaert, Philippe Delannoy, et al.. Epithelial mucins and bacterial adhesion. Carbohydrate Chemistry: Chemical and Biological Approaches, Volume 40, The Royal Society of Chemistry, pp.596-623, 2014, ⟨10.1039/9781849739986-00596⟩. ⟨hal-00949086⟩

Collections

CNRS UNIV-LILLE
47 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More