Synthesis, characterization, X-ray structure, DNA cleavage and cytotoxic activities of palladium(II) complexes of 4-phenyl-3-thiosemicarbazide and triphenylphosphine. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Inorganic Chemistry Année : 2013

Synthesis, characterization, X-ray structure, DNA cleavage and cytotoxic activities of palladium(II) complexes of 4-phenyl-3-thiosemicarbazide and triphenylphosphine.

Résumé

Complexes of the type [PdX(PPh3)(1)]X [1 = 4-phenyl-3-thiosemicarbazide; X = Cl- (2), Br- (3), I- (4), and SCN- (5)] have been synthesized and characterized by elemental analyses and IR, UV/Vis, and 1H and 13C NMR spectroscopy. The molecular structure of complex 4 was determined by single-crystal X-ray diffraction. The binding of the complexes with a purine base (guanosine) was investigated by 1H NMR spectroscopy and mass spectrometry, which showed the complexes to coordinate to guanosine through N7. A gel electrophoresis assay demonstrated the ability of 2-5 to cleave DNA plasmid. All the complexes were tested in vitro by means of the MTT assay for their cytotoxicity against two murine cell lines, LM3 (mammary adenocarcinoma) and LP07 (lung adenocarcinoma), and compared with cisplatin. Complexes 2-5 exhibited good cytotoxicity that surpasses that of cisplatin in the case of LM3.
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Dates et versions

hal-00948885 , version 1 (18-02-2014)

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  • HAL Id : hal-00948885 , version 1

Citer

Fillipe Vieira Rocha, Carolina Valério Barra, Antonio Eduardo Mauro, Iracilda Z. Carlos, Lionel Nauton, et al.. Synthesis, characterization, X-ray structure, DNA cleavage and cytotoxic activities of palladium(II) complexes of 4-phenyl-3-thiosemicarbazide and triphenylphosphine.. European Journal of Inorganic Chemistry, 2013, pp.4499-4505. ⟨hal-00948885⟩
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