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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2014

Synthesis and evaluation of cytotoxic activities of new guanidines derived from carbazoles.

Résumé

Several new alkylguanidines derived from carbazole have been synthesized in a simple one-pot reaction starting from 3-aminocarbazole derivatives. The aminocarbazoles were reacted with ethoxycarbonylisothiocyanate, to give thiourea intermediates, followed by the addition of an alkylamine and HgCl2 to give ethoxycarbonylguanidine intermediates. The reaction mixture was then heated at 160°C to give the N-(1,4-dimethyl-9H-carbazol-3-yl)-N'-alkylguanidines. The cytotoxic activity of all the synthesized guanidines was evaluated against different cell lines.

Domaines

Chimie organique
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Dates et versions

hal-00945836 , version 1 (13-02-2014)

Identifiants

Citer

Anna Caruso, Maria Stefania Sinicropi, Jean-Charles Lancelot, Hussein El-Kashef, Carmela Saturnino, et al.. Synthesis and evaluation of cytotoxic activities of new guanidines derived from carbazoles.. Bioorganic and Medicinal Chemistry Letters, 2014, 24 (2), pp.467-72. ⟨10.1016/j.bmcl.2013.12.047⟩. ⟨hal-00945836⟩
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