Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Phytochemistry Année : 2013

Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402.

Thiago M Casella
  • Fonction : Auteur
Hugues Mandavid
  • Fonction : Auteur
Audrey Bendelac
  • Fonction : Auteur
Guillaume Odonne
Laura Dayan
  • Fonction : Auteur
Christophe Duplais
Laila S Espindola
  • Fonction : Auteur
Didier Stien

Résumé

Because of the symbiotic nature of endophytes, this survey aims to investigate the probability of discovering antibacterial, antifungal and cytotoxic activities in leaf endophytic microbes. We isolated 138 cultivable microbes (121 fungi, 3 bacteria and 14 unidentified or unknown microbes) from 24 plant species, a significant relative proportion of which exhibited antifungal and cytotoxic potential against Candida albicans ATCC 10213 and the human cell lines KB (uterine cervical carcinoma), MDA-MB-435 (melanoma), and MRC5 (normal human lung fibroblasts). Three active fungal extracts were fractionated, resulting in the isolation of eight compounds. Seven had been described in the literature including the following: acremonisol A, semicochliodinol A, cochliodinol, griseofulvin, pyrenocin A, novae zelandin A and alterperylenol. A previously unreported compound named pyrrocidine C was isolated from Lewia infectoria SNB-GTC2402 and identified by spectroscopic analysis. As in pyrrocidines A and B, this compound is a cis-substituted decahydrofluorene with a quaternary carbon at C-5 and opposite stereochemistry at C-8 corresponding to C-6 of pyrrocidines A and B.

Domaines

Chimie organique

Dates et versions

hal-00945536 , version 1 (12-02-2014)

Identifiants

Citer

Thiago M Casella, Véronique Eparvier, Hugues Mandavid, Audrey Bendelac, Guillaume Odonne, et al.. Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402.. Phytochemistry, 2013, 96, pp.370-7. ⟨10.1016/j.phytochem.2013.10.004⟩. ⟨hal-00945536⟩
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