Bisimulation up-to enhances the coinductive proof method for bisimilarity, providing efficient proof techniques for checking properties of different kinds of systems. We prove the soundness of such techniques in a fibrational setting, building on the seminal work of Hermida and Jacobs. This allows us to systematically obtain up-to techniques not only for bisimilarity but for a large class of coinductive predicates modelled as coalgebras. By tuning the parameters of our framework, we obtain novel techniques for unary predicates and nominal automata, a variant of the GSOS rule format for similarity, and a new categorical treatment of weak bisimilarity.