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Article Dans Une Revue Veterinary Research Année : 2006

Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa

Eric Cox
  • Fonction : Auteur
Frank Verdonck
  • Fonction : Auteur
Daisy Vanrompay
  • Fonction : Auteur
Bruno Goddeeris
  • Fonction : Auteur

Résumé

In developing veterinary mucosal vaccines and vaccination strategies, mucosal adjuvants are one of the key players for inducing protective immune responses. Most of the mucosal adjuvants seem to exert their effect via binding to a receptor/or target cells and these properties were used to classify the mucosal adjuvants reviewed in the present paper: (1) ganglioside receptor-binding toxins (cholera toxin, LT enterotoxin, their B subunits and mutants); (2) surface immunoglobulin binding complex CTA1-DD; (3) TLR4 binding lipopolysaccharide; (4) TLR2-binding muramyl dipeptide; (5) Mannose receptor-binding mannan; (6) Dectin-1-binding ß 1,3/1,6 glucans; (7) TLR9-binding CpG-oligodeoxynucleotides; (8) Cytokines and chemokines; (9) Antigen-presenting cell targeting ISCOMATRIX and ISCOM. In addition, attention is given to two adjuvants able to prime the mucosal immune system following a systemic immunization, namely 1$\alpha$, 25(OH)2D3 and cholera toxin.
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Dates et versions

hal-00903037 , version 1 (11-05-2020)

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Eric Cox, Frank Verdonck, Daisy Vanrompay, Bruno Goddeeris. Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa. Veterinary Research, 2006, 37 (3), pp.511-539. ⟨10.1051/vetres:2006014⟩. ⟨hal-00903037⟩
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