The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle - Archive ouverte HAL
Article Dans Une Revue Veterinary Research Année : 2008

The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle

Stefanie de Schepper
  • Fonction : Auteur
Adelheid de Ketelaere
  • Fonction : Auteur
Douglas Bannerman
  • Fonction : Auteur
Max Paape
  • Fonction : Auteur
Luc Peelman
  • Fonction : Auteur
Christian Burvenich
  • Fonction : Auteur

Résumé

Mastitis is one of the most costly production diseases in the dairy industry that is caused by a wide array of microorganisms. In this review, we focus on the Gram-negative Escherichia coli infections that often occur at periods when the innate immune defence mechanisms are impaired (i.e., parturition through the first 60 days of lactation). There is substantial evidence demonstrating that at these periods, the expected influx of polymorphonuclear neutrophil leukocytes (PMN) into the mammary gland is delayed during inflammation after intramammary infection with E. coli. Here, we provide some hypotheses on the potential mechanisms of action on how the disease may develop under circumstances of immunosuppression, and describe the potential involvement of the toll-like receptor-4 signal transduction pathway in the pathogenesis of E. coli mastitis. In addition, some ideas are proposed to help prevent E. coli mastitis and potentially other diseases caused by Gram-negative infections in general.
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hal-00902871 , version 1 (11-05-2020)

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Stefanie de Schepper, Adelheid de Ketelaere, Douglas Bannerman, Max Paape, Luc Peelman, et al.. The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle. Veterinary Research, 2008, 39 (1), pp.1-23. ⟨10.1051/vetres:2007044⟩. ⟨hal-00902871⟩
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