Myxoma virus in the European rabbit: interactions between the virus and its susceptible host - Archive ouverte HAL
Article Dans Une Revue Veterinary Research Année : 2007

Myxoma virus in the European rabbit: interactions between the virus and its susceptible host

Marianne Stanford
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Steven Werden
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Grant Mcfadden
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Résumé

Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host/poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.
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Dates et versions

hal-00902835 , version 1 (11-05-2020)

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Marianne Stanford, Steven Werden, Grant Mcfadden. Myxoma virus in the European rabbit: interactions between the virus and its susceptible host. Veterinary Research, 2007, 38 (2), pp.299-318. ⟨10.1051/vetres:2006054⟩. ⟨hal-00902835⟩
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