Article Dans Une Revue Veterinary Research Année : 2004

Characterization of a novel activation antigen on porcine lymphocytes recognized by monoclonal antibody 5A6/8

Nieves Doménech
  • Fonction : Auteur
Rosario Bullido
  • Fonction : Auteur
Belén Álvarez
  • Fonction : Auteur
Emilia Campos
  • Fonction : Auteur
Manuel Gómez del Moral
  • Fonction : Auteur
Fernando Alonso
  • Fonction : Auteur
Ángel Ezquerra
  • Fonction : Auteur
Javier Domínguez
  • Fonction : Auteur

Résumé

In this report, we describe the characterization of a novel activation antigen on porcine lymphocytes recognized by mAb 5A6/8. This antigen was detected on B and T cells 24 h after treatment with various stimuli. It was also found on alveolar macrophages, and at low levels on untreated monocytes. MAb 5A6/8 precipitated two bands of 45 and 50 kDa under non-reducing conditions, and of 22 and 28 kDa under reducing conditions. The cellular distribution, expression kinetics and/or molecular size of the 5A6/8 antigen differ from those of other known lymphocyte activation antigens. MAb 5A6/8 was able to inhibit lymphocyte proliferative responses driven by different stimuli, suggesting a role for this molecule in the events that lead to lymphocyte activation.

Fichier principal
Vignette du fichier
hal-00902787.pdf (732.07 Ko) Télécharger le fichier
Origine Accord explicite pour ce dépôt
Licence
Loading...

Dates et versions

hal-00902787 , version 1 (11-05-2020)

Licence

Identifiants

Citer

Nieves Doménech, Rosario Bullido, Belén Álvarez, Emilia Campos, María-Pilar Rodríguez-Carreño, et al.. Characterization of a novel activation antigen on porcine lymphocytes recognized by monoclonal antibody 5A6/8. Veterinary Research, 2004, 35 (3), pp.339-348. ⟨10.1051/vetres:2004017⟩. ⟨hal-00902787⟩
89 Consultations
150 Téléchargements

Altmetric

Partager

  • More