A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle - Archive ouverte HAL Access content directly
Journal Articles Veterinary Research Year : 2003

A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle

Céline M. Laffont
  • Function : Author
Alain Bousquet‐mélou
  • Function : Author
  • PersonId : 1207361
David Bralet
  • Function : Author
Michel Alvinerie
  • Function : Author
Johanna Fink-Gremmels
  • Function : Author
Pierre-Louis Toutain

Abstract

Ivermectin is a worldwide-used antiparasitic drug largely administered to cattle as a topical formulation (pour-on). The actual plasma and faecal disposition of pour-on ivermectin in cattle was documented using an original pharmacokinetic model, and taking into account the oral ingestion of the topical drug following physiological licking as a secondary route of exposure. Six pairs of monozygotic twin cattle received successively one i.v. and two pour-on administrations of ivermectin at a 3-5-month interval. For one pour-on administration, the twins were separated into an unrestrained group and a group where self- and allo-licking were prevented. Ivermectin concentrations in the plasma and faeces were determined by HPLC. Licking resulted in a high intra-and inter-individual variability of systemic exposure after topical application. By the means of pharmacokinetic modelling, we showed that 58-87% of the pour-on dose was ingested, while only 10% was absorbed percutaneously. Approximately 72% of the ingested ivermectin transited directly into the faeces, resulting in a 7-fold higher faecal excretion of the parent drug than in the non-lickers. We conclude that topical administration does not guarantee a controlled drug delivery in cattle. More importantly, the simulations revealed that non-treated cattle could get easily contaminated by allo-licking, raising the public health problem of unexpected drug residues in edible tissues.
Fichier principal
Vignette du fichier
hal-00902759.pdf (471.95 Ko) Télécharger le fichier
Origin : Explicit agreement for this submission
Loading...

Dates and versions

hal-00902759 , version 1 (11-05-2020)

Licence

Copyright

Identifiers

Cite

Céline M. Laffont, Alain Bousquet‐mélou, David Bralet, Michel Alvinerie, Johanna Fink-Gremmels, et al.. A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle. Veterinary Research, 2003, 34 (4), pp.445-460. ⟨10.1051/vetres:2003014⟩. ⟨hal-00902759⟩
112 View
629 Download

Altmetric

Share

Gmail Facebook X LinkedIn More