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            <idno type="halRefHtml">&lt;i&gt;Reproduction Nutrition Development&lt;/i&gt;, 2003, 43 (2), pp.145-154. &lt;a target="_blank" href="https://dx.doi.org/10.1051/rnd:2003014"&gt;&amp;#x27E8;10.1051/rnd:2003014&amp;#x27E9;&lt;/a&gt;</idno>
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                <title xml:lang="en">Intestinal absorption of $^{14}$C from $^{14}$C-phenanthrene, $^{14}$C-benzo[a]pyrene and $^{14}$C-tetrachlorodibenzo-para-dioxin: approaches with the Caco-2 cell line and with portal absorption measurements in growing pigs</title>
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                <title level="j">Reproduction Nutrition Development</title>
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                <term xml:lang="es">intestinal transfer</term>
                <term xml:lang="es">PAHs</term>
                <term xml:lang="es">dioxin</term>
                <term xml:lang="es">Caco-2</term>
                <term xml:lang="es">portal absorption</term>
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              <p>The aim of this work was to study the transfer through the intestinal barrier of two polycyclic aromatic hydrocarbons (PAHs) (benzo[a]pyrene and phenanthrene) and a dioxin (2,3,7,8-tetrachlorodibenzo-para-dioxin) which differed in their physicochemical properties. Both in vitro and in vivo assays were performed. For the in vitro study, Caco-2 cells, cultivated on permeable filters, permitted to measure the transepithelial permeability of the studied $^{14}$C-labelled molecules. For the in vivo study, portal absorption kinetics were evaluated in pigs fed contamined milk. The results showed that all the molecules were absorbed and demonstrated a differential intestinal absorption for the studied molecules. Phenanthrene appeared to be the fastest and most uptaken compound, followed by benzo[a]pyrene and finally 2,3,7,8-tetrachlorodibenzo-para-dioxin. Their absorption levels were respectively 9.5, 5.2 and 1.4% after a 6 h-exposure in vitro and 86.1, 30.5 and 8.3% in vivo for the 24 h following ingestion. These findings suggest that the physicochemical properties of the xenobiotics and intestinal epithelium play key roles in the selective permeability and in the bioavailability of the tested micropollutants.</p>
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