A bivariate quantitative genetic model for a linear Gaussian trait and a survival trait - Archive ouverte HAL
Article Dans Une Revue Genetics Selection Evolution Année : 2006

A bivariate quantitative genetic model for a linear Gaussian trait and a survival trait

Lars Holm Damgaard
  • Fonction : Auteur
Inge Riis Korsgaard
  • Fonction : Auteur

Résumé

With the increasing use of survival models in animal breeding to address the genetic aspects of mainly longevity of livestock but also disease traits, the need for methods to infer genetic correlations and to do multivariate evaluations of survival traits and other types of traits has become increasingly important. In this study we derived and implemented a bivariate quantitative genetic model for a linear Gaussian and a survival trait that are genetically and environmentally correlated. For the survival trait, we considered the Weibull log-normal animal frailty model. A Bayesian approach using Gibbs sampling was adopted. Model parameters were inferred from their marginal posterior distributions. The required fully conditional posterior distributions were derived and issues on implementation are discussed. The two Weibull baseline parameters were updated jointly using a Metropolis-Hasting step. The remaining model parameters with non-normalized fully conditional distributions were updated univariately using adaptive rejection sampling. Simulation results showed that the estimated marginal posterior distributions covered well and placed high density to the true parameter values used in the simulation of data. In conclusion, the proposed method allows inferring additive genetic and environmental correlations, and doing multivariate genetic evaluation of a linear Gaussian trait and a survival trait.
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Dates et versions

hal-00894559 , version 1 (11-05-2020)

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  • HAL Id : hal-00894559 , version 1

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Lars Holm Damgaard, Inge Riis Korsgaard. A bivariate quantitative genetic model for a linear Gaussian trait and a survival trait. Genetics Selection Evolution, 2006, 38 (1), pp.45-64. ⟨hal-00894559⟩
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