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Article Dans Une Revue CrystEngComm Année : 2013

A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect?

Résumé

A novel, biocompatible, calcium-based coordination polymer was hydrothermally synthesized using as linker the bone antiresorptive bisphosphonate alendronate. Its structure was determined using single-crystal X-ray diffraction and characterized by chemical analysis, infrared spectroscopy (IR), X-ray powder diffraction (XRPD), solid state nuclear magnetic resonance (NMR) and thermogravimetric analysis (TGA). Its bioactivity was finally evaluated in vitro, revealing a very high stability towards simulated body fluid.

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Dates et versions

hal-00881213 , version 1 (07-11-2013)

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Elsa Alvarez, Alfonso Garcia-Marquez, Thomas Devic, Nathalie Steunou, Christian Serre, et al.. A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect?. CrystEngComm, 2013, 15, pp.9899. ⟨10.1039/c3ce41346b⟩. ⟨hal-00881213⟩
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