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Article Dans Une Revue Soft Matter Année : 2012

Probing in cell protein structural changes with time-resolved X-ray scattering

Alessandro Spilotros
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Matteo Levantino
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Giorgio Schirò
Marco Cammarata
Antonio Cupane
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Résumé

Investigating protein structural changes inside the cell is a major goal in molecular biology. Here we show that time-resolved wide-angle X-ray scattering is a valuable tool for this purpose. Hemoglobin has been chosen as a model system and its tertiary and quaternary conformational changes following laser flash-photolysis have been tracked in intact red blood cells with nanosecond time resolution.

Dates et versions

hal-00874214 , version 1 (17-10-2013)

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Alessandro Spilotros, Matteo Levantino, Giorgio Schirò, Marco Cammarata, Michael Wulff, et al.. Probing in cell protein structural changes with time-resolved X-ray scattering. Soft Matter, 2012, 8 (24), pp.6434-6437. ⟨10.1039/C2SM25676B⟩. ⟨hal-00874214⟩
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