The mechanical behaviors of α-Zr and α-Ti with various oxygen and hydrogen contents were investigated by loading/relaxation/unloading tensile tests and tests with strain rate jumps, at 300°C and 20°C, respectively. Solute oxygen and hydrogen atoms were found to have antagonist effects. While the former increases the yield stress and hardening exponent, reduces the activation volume and enhances static and dynamic strain aging phenomena, the latter significantly reduces these effects, as long as the O content is not too high.