Palladium-catalyzed direct arylation using free NH2 substituted thiophene derivatives with inhibition of amination type reaction - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Tetrahedron Année : 2012

Palladium-catalyzed direct arylation using free NH2 substituted thiophene derivatives with inhibition of amination type reaction

Résumé

The palladium-catalyzed direct arylation at C2 or C5 of free NH2 substituted thiophene derivatives was found to proceed in moderate to high yields using a variety of aryl halides. The choice of potassium acetate as the base was found to be crucial to inhibit the amination reaction and to promote the direct arylation.

Domaines

Catalyse

Dates et versions

hal-00870565 , version 1 (07-10-2013)

Identifiants

Citer

Fazia Derridj, Karima Si larbi, Julien Roger, Safia Djabbar, Henri Doucet. Palladium-catalyzed direct arylation using free NH2 substituted thiophene derivatives with inhibition of amination type reaction. Tetrahedron, 2012, 68 (36), pp.7463-7471. ⟨10.1016/j.tet.2012.06.053⟩. ⟨hal-00870565⟩
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