N-Arylsulfonyl-2-vinyltryptamines as new 5-HT6 serotonin receptor Ligands - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Enzyme Inhibition and Medicinal Chemistry Année : 2006

N-Arylsulfonyl-2-vinyltryptamines as new 5-HT6 serotonin receptor Ligands

Résumé

Several new 2-vinyl-Nb,Nb-dimethyltryptamines were prepared using Fischer indole synthesis followed by simple functional group transformations and evaluated on 5-HT4, 5-HT5, 5-HT6 and 5-HT7 serotonin receptors. It was found that 2-vinyl substitution conferred a potent and selective 5-HT6 binding activity to these molecules which could be enhanced by Na-arylsulfonyl substituents.

Domaines

Neurosciences

Dates et versions

hal-00867881 , version 1 (30-09-2013)

Identifiants

Citer

Marion Raoul, Dominique Patigny, Frédéric Fabis, François Dauphin, Sylvain Rault, et al.. N-Arylsulfonyl-2-vinyltryptamines as new 5-HT6 serotonin receptor Ligands. Journal of Enzyme Inhibition and Medicinal Chemistry, 2006, 21, pp.251-260. ⟨10.1080/14756360600700285⟩. ⟨hal-00867881⟩
79 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More