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Article Dans Une Revue Nature Protocols Année : 2009

The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice.

Résumé

Long-term functional deficits after a brain injury are difficult to assess in the mouse. If no deficit is observed, researchers could conclude either that the animal has fully recovered or that the tests they used were not appropriate or sensitive enough to the modality of the deficits. We present here a detailed protocol describing how to conduct an adhesive removal test for this species. It consists of applying adhesive tape on each forepaw of the animal and measuring the time-to-contact and the time-to-remove them. This behavior implies correct paw and mouth sensitivity (time-to-contact) and correct dexterity (time-to-remove). To decrease interindividual differences, we recommend a training session (1 week, 1 trial per day) before surgical procedures so that mice to reach optimal performances.

Domaines

Neurosciences
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Dates et versions

hal-00863258 , version 1 (18-09-2013)

Identifiants

Citer

Valentine Bouet, Michel Boulouard, Jérôme Toutain, Didier Divoux, Myriam Bernaudin, et al.. The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice.. Nature Protocols, 2009, 4 (10), pp.1560-4. ⟨10.1038/nprot.2009.125⟩. ⟨hal-00863258⟩
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