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Article Dans Une Revue Neuron Année : 2013

Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.

Ludmilla Lokmane
  • Fonction : Auteur
Caroline Mailhes
  • Fonction : Auteur
Maryama Keita
  • Fonction : Auteur
Michio Yoshida
  • Fonction : Auteur
Yutaka Yoshida
  • Fonction : Auteur
Fanny Mann
  • Fonction : Auteur
  • PersonId : 997576
  • IdHAL : fanny-mann
Elizabeth A Grove
  • Fonction : Auteur
Sonia Garel

Résumé

Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical neuron identity and suggest that CTAs and thalamic axons may guide each other, but the mechanisms governing CTA versus CSA pathfinding remain elusive. Here, we show that thalamocortical axons are required to guide pioneer CTAs away from a default CSA-like trajectory. This process relies on a hold in the progression of cortical axons, or waiting period, during which thalamic projections navigate toward cortical axons. At the molecular level, Sema3E/PlexinD1 signaling in pioneer cortical neurons mediates a "waiting signal" required to orchestrate the mandatory meeting with reciprocal thalamic axons. Our study reveals that temporal control of axonal progression contributes to spatial pathfinding of cortical projections and opens perspectives on brain wiring.

Dates et versions

hal-00862141 , version 1 (16-09-2013)

Identifiants

Citer

Marie Deck, Ludmilla Lokmane, Sophie Chauvet, Caroline Mailhes, Maryama Keita, et al.. Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.. Neuron, 2013, 77 (3), pp.472-84. ⟨10.1016/j.neuron.2012.11.031⟩. ⟨hal-00862141⟩
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