<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00859209</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-21T09:59:38+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Dietary cholesterol: from physiology to cardiovascular risk.</title>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Michel</forename>
                <surname>Lecerf</surname>
              </persName>
              <email type="md5">8a953571f70d8bb8f2287b3c5be2fc50</email>
              <email type="domain">pasteur-lille.fr</email>
              <idno type="idhal" notation="numeric">769209</idno>
              <idno type="halauthorid" notation="string">732027-769209</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9127-0158</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>de Lorgeril</surname>
              </persName>
              <email type="md5">bbff3ab0ad64c86a0ad80d45f1a942f5</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="idhal" notation="numeric">943451</idno>
              <idno type="halauthorid" notation="string">253071-943451</idno>
              <affiliation ref="#struct-388395"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Michel</forename>
                <surname>De Lorgeril</surname>
              </persName>
              <email type="md5">19261a10c9516d8d4e84cd1e1cf92347</email>
              <email type="domain">ujf-grenoble.fr.invalid</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-09-06 16:25:58</date>
              <date type="whenModified">2025-09-27 19:03:52</date>
              <date type="whenReleased">2013-09-06 16:25:58</date>
              <date type="whenProduced">2011-07</date>
              <ref type="externalLink" target="https://www.cambridge.org/core/services/aop-cambridge-core/content/view/2AD4493E735677B9298CCC17FA790539/S0007114511000237a.pdf/div-class-title-dietary-cholesterol-from-physiology-to-cardiovascular-risk-div.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="138889">
                <persName>
                  <forename>Michel</forename>
                  <surname>De Lorgeril</surname>
                </persName>
                <email type="md5">19261a10c9516d8d4e84cd1e1cf92347</email>
                <email type="domain">ujf-grenoble.fr.invalid</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00859209</idno>
            <idno type="halUri">https://hal.science/hal-00859209</idno>
            <idno type="halBibtex">lecerf:hal-00859209</idno>
            <idno type="halRefHtml">&lt;i&gt;Br J Nutr&lt;/i&gt;, 2011, 106 (1), pp.6-14. &lt;a target="_blank" href="https://dx.doi.org/10.1017/S0007114511000237"&gt;&amp;#x27E8;10.1017/S0007114511000237&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Br J Nutr, 2011, 106 (1), pp.6-14. &amp;#x27E8;10.1017/S0007114511000237&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="CARDIO" corresp="INSERM">Cardiovasculaire</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-PRETA" corresp="TIMC-IMAG">PRETA : Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Dietary cholesterol: from physiology to cardiovascular risk.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Michel</forename>
                    <surname>Lecerf</surname>
                  </persName>
                  <email type="md5">8a953571f70d8bb8f2287b3c5be2fc50</email>
                  <email type="domain">pasteur-lille.fr</email>
                  <idno type="idhal" notation="numeric">769209</idno>
                  <idno type="halauthorid" notation="string">732027-769209</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9127-0158</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>de Lorgeril</surname>
                  </persName>
                  <email type="md5">bbff3ab0ad64c86a0ad80d45f1a942f5</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">943451</idno>
                  <idno type="halauthorid" notation="string">253071-943451</idno>
                  <affiliation ref="#struct-388395"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="INCOMING">37394</idno>
                <title level="j">Br J Nutr</title>
                <imprint>
                  <biblScope unit="volume">106</biblScope>
                  <biblScope unit="issue">1</biblScope>
                  <biblScope unit="pp">6-14</biblScope>
                  <date type="datePub">2011-07</date>
                  <date type="dateEpub">2011-03-09</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1017/S0007114511000237</idno>
              <idno type="pubmed">21385506</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Cardiovascular Diseases</classCode>
              <classCode scheme="mesh">Cholesterol</classCode>
              <classCode scheme="mesh">Cholesterol, Dietary</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Intestinal Absorption</classCode>
              <classCode scheme="mesh">Phytosterols</classCode>
              <classCode scheme="mesh">Risk Factors</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.csc">Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Dietary cholesterol comes exclusively from animal sources, thus it is naturally present in our diet and tissues. It is an important component of cell membranes and a precursor of bile acids, steroid hormones and vitamin D. Contrary to phytosterols (originated from plants), cholesterol is synthesised in the human body in order to maintain a stable pool when dietary intake is low. Given the necessity for cholesterol, very effective intestinal uptake mechanisms and enterohepatic bile acid and cholesterol reabsorption cycles exist; conversely, phytosterols are poorly absorbed and, indeed, rapidly excreted. Dietary cholesterol content does not significantly influence plasma cholesterol values, which are regulated by different genetic and nutritional factors that influence cholesterol absorption or synthesis. Some subjects are hyper-absorbers and others are hyper-responders, which implies new therapeutic issues. Epidemiological data do not support a link between dietary cholesterol and CVD. Recent biological data concerning the effect of dietary cholesterol on LDL receptor-related protein may explain the complexity of the effect of cholesterol on CVD risk.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-388395" status="OLD">
          <orgName>Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</orgName>
          <orgName type="acronym">TIMC-IMAG-PRETA</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr/preta</ref>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>