This chapter sheds light on urban freight transportation and city logistics. It identifies the key issues and challenges in the supply and shipment of goods to and from large urban areas from Europe, Japan, North America, as well as emerging and developing countries. A comprehensive review of data is presented, showing that urban freight statistics do exist in many cities but data collections are made in a piecemeal approach and with very different methods, making comparisons difficult. Overall, urban freight has become crucial to modern urban economies, as customized and more frequent deliveries are required by stores, businesses and households. The chapter presents issues such as trucks’ environmental impacts, goods movement’s inefficiencies, and 'logistics sprawl', i.e. the location of warehouses in suburban areas. Strategies and policies are presented, showing the emerging field of 'city logistics', i.e. innovative projects for clean and energy efficient urban deliveries. Local policies from cities around the world are presented and compared, showing the difficulties for many local governments to manage and regulate urban goods movements, whose drivers are global supply chains and changing consumer demands. Some success stories are presented such as London’s Low Emission Zone, Motomachi Urban Consolidation Center, the Clean Truck Program in Los Angeles ports.