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Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2009

Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.

Carmela Giglione
Thierry Meinnel

Résumé

Bacillus subtilis mutants with resistance against peptide deformylase inhibitors were isolated. All showed a bypass of the pathway through mutations in three genes required for formylation of Met-tRNA(fMet), fmt, folD, and glyA. glyA corresponds to a yet uncharacterized locus inducing resistance. The bypass of formylation caused robust fitness reduction but was not accompanied by alterations of the transcription profile. A subtle adaptation of the enzymes of the intermediary metabolism was observed.

Dates et versions

hal-00853802 , version 1 (23-08-2013)

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Citer

Yann Duroc, Carmela Giglione, Thierry Meinnel. Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.. Antimicrobial Agents and Chemotherapy, 2009, 53 (4), pp.1673-8. ⟨10.1128/AAC.01340-08⟩. ⟨hal-00853802⟩
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