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Article Dans Une Revue Organic Letters Année : 2013

First Synthesis of a Stable Isotope of Ochratoxin A Metabolite for a Reliable Detoxification Monitoring

Résumé

Due to its toxicity and presence in numerous food products, Ochratoxin A (OTA) has drawn attention for decades. This article summarizes the first synthesis of a labeled analogue of Ochratoxin R (OTR), one of the main products generated by the metabolization of OTA by microorganisms. This synthesis also led to a new labeled analogue of OTA with the deuteration located on the dihydroisocoumarin moiety allowing thus both the accurate quantification of OTA and OTR and the establishing of a reliable detoxification rate.

Domaines

Chimie organique
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Dates et versions

hal-00852056 , version 1 (19-08-2013)

Identifiants

Citer

Anaïs Bouisseau, Aurélie Roland, Florence Reillon, Rémi Schneider, Florine Cavelier. First Synthesis of a Stable Isotope of Ochratoxin A Metabolite for a Reliable Detoxification Monitoring. Organic Letters, 2013, 15 (15), pp.3888-3890. ⟨10.1021/ol401630t⟩. ⟨hal-00852056⟩
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