Dependence receptors: from basic research to drug development. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Science Signaling Année : 2011

Dependence receptors: from basic research to drug development.

Résumé

The fourth meeting on dependence receptors featured descriptions of previously unknown dependence receptors. New mechanistic data were presented on the switch between the trophic, antiapoptotic response with the proapoptotic response that occurs with loss of trophic support. The possibility that the loss of trophic support may also involve the binding of an active antitrophin was also discussed. New in vivo data were presented on the roles of dependence receptors in development, angiogenesis, oncogenesis, and neurodegeneration, as well as new therapeutic approaches based on dependence receptor function. The next meeting on dependence receptors is scheduled for 2012.

Domaines

Cancer
Fichier non déposé

Dates et versions

hal-00850822 , version 1 (08-08-2013)

Identifiants

Citer

Patrick Mehlen, Dale E Bredesen. Dependence receptors: from basic research to drug development.. Science Signaling, 2011, 4 (157), pp.mr2. ⟨10.1126/scisignal.2001521⟩. ⟨hal-00850822⟩
32 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More