Pharmacological exposure to ribavirin: a key player in the complex network of factors implicated in virological response and anaemia in hepatitis C treatment. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Digestive and Liver Disease Année : 2011

Pharmacological exposure to ribavirin: a key player in the complex network of factors implicated in virological response and anaemia in hepatitis C treatment.

Paul Carrier
  • Fonction : Auteur
Gérard Babany
  • Fonction : Auteur
Denis Sautereau
  • Fonction : Auteur
Non Renseigné
  • Fonction : Auteur

Résumé

Ribavirin remains today a pivotal drug in the treatment of hepatitis C; in standard double therapy, as well as in triple combination with direct antiviral agents, ribavirin reduces relapse and can double the sustained virological response obtained with peginterferon alone or in association with direct antiviral agents. In the complex network of interacting factors determining sustained virological response independently of known predictive factors related to host and virus, two modern tools are emerging: polymorphisms in the IL28B gene and very early exposure to ribavirin. The use of a pharmacokinetic-pharmacodynamic model of early ribavirin exposure to adjust the dose individually would help promote a safer ribavirin use and improve sustained virological response. The variability of the influence of ribavirin exposure on anaemia is probably genetically determined; however, the low prevalence of the implicated protective alleles of the inosine triphosphate pyrophosphatase gene could explain their lack of influence on sustained virological response.

Domaines

Cancer

Dates et versions

hal-00850161 , version 1 (05-08-2013)

Identifiants

Citer

Véronique Loustaud-Ratti, Paul Carrier, Annick Rousseau, Marianne Maynard, Gérard Babany, et al.. Pharmacological exposure to ribavirin: a key player in the complex network of factors implicated in virological response and anaemia in hepatitis C treatment.. Digestive and Liver Disease, 2011, 43 (11), pp.850-5. ⟨10.1016/j.dld.2011.04.002⟩. ⟨hal-00850161⟩
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