<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00849673</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-23T01:13:13+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The prognosis of CALM-AF10 positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.</title>
            <author role="aut">
              <persName>
                <forename type="first">Raouf</forename>
                <surname>Ben Abdelali</surname>
              </persName>
              <idno type="halauthorid">685018-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vahid</forename>
                <surname>Asnafi</surname>
              </persName>
              <idno type="halauthorid">220924-0</idno>
              <affiliation ref="#struct-301664"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Petit</surname>
              </persName>
              <email type="md5">8b51dd807fe5c7514c6cc8a6ef824062</email>
              <email type="domain">aphp.fr</email>
              <idno type="idhal" notation="string">arnaudpetit</idno>
              <idno type="idhal" notation="numeric">1903</idno>
              <idno type="halauthorid" notation="string">14639-1903</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-1633-2011</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8363-1622</idno>
              <idno type="IDREF">https://www.idref.fr/087801582</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-1633-2011</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Baptiste</forename>
                <surname>Micol</surname>
              </persName>
              <idno type="halauthorid">726070-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Céline</forename>
                <surname>Callens</surname>
              </persName>
              <idno type="halauthorid">433335-0</idno>
              <affiliation ref="#struct-1288"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrick</forename>
                <surname>Villarese</surname>
              </persName>
              <idno type="halauthorid">726071-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Delabesse</surname>
              </persName>
              <email type="md5">103e09ad32d1970bffff4833d3b433d4</email>
              <email type="domain">iuct-oncopole.fr</email>
              <idno type="idhal" notation="string">delabesse</idno>
              <idno type="idhal" notation="numeric">1440591</idno>
              <idno type="halauthorid" notation="string">726072-1440591</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0928-0753</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/I-5221-2016</idno>
              <idno type="IDREF">https://www.idref.fr/104535237</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/I-5221-2016</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Oumedaly</forename>
                <surname>Reman</surname>
              </persName>
              <idno type="halauthorid">440253-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stephane</forename>
                <surname>Lepretre</surname>
              </persName>
              <idno type="halauthorid">685020-0</idno>
              <affiliation ref="#struct-46229"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean Yves</forename>
                <surname>Cahn</surname>
              </persName>
              <idno type="halauthorid">461385-0</idno>
              <affiliation ref="#struct-388270"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gaelle</forename>
                <surname>Guillerm</surname>
              </persName>
              <idno type="halauthorid">578108-0</idno>
              <affiliation ref="#struct-165418"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Céline</forename>
                <surname>Berthon</surname>
              </persName>
              <idno type="idhal" notation="numeric">767888</idno>
              <idno type="halauthorid" notation="string">690795-767888</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3474-2577</idno>
              <affiliation ref="#struct-545691"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claude</forename>
                <surname>Gardin</surname>
              </persName>
              <idno type="halauthorid">440254-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bernadette</forename>
                <surname>Corront</surname>
              </persName>
              <idno type="halauthorid">440610-0</idno>
              <affiliation ref="#struct-447517"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Thibaut</forename>
                <surname>Leguay</surname>
              </persName>
              <idno type="halauthorid">685019-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Christine</forename>
                <surname>Béné</surname>
              </persName>
              <email type="md5">1a9a93d17fa8a57c40f7eb287ac04f33</email>
              <email type="domain">medecine.uhp-nancy.fr</email>
              <idno type="idhal" notation="numeric">767851</idno>
              <idno type="halauthorid" notation="string">392386-767851</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6569-7414</idno>
              <idno type="IDREF">https://www.idref.fr/028595823</idno>
              <affiliation ref="#struct-221698"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Norbert</forename>
                <surname>Ifrah</surname>
              </persName>
              <email type="md5">5342c0438e9c786f1c3f15588e5818e1</email>
              <email type="domain">chu-angers.fr</email>
              <idno type="idhal" notation="numeric">1432242</idno>
              <idno type="halauthorid" notation="string">440621-1432242</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3063-850X</idno>
              <affiliation ref="#struct-99728"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guy</forename>
                <surname>Leverger</surname>
              </persName>
              <idno type="halauthorid">153758-0</idno>
              <affiliation ref="#struct-360410"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hervé</forename>
                <surname>Dombret</surname>
              </persName>
              <idno type="idhal" notation="numeric">759753</idno>
              <idno type="halauthorid" notation="string">312283-759753</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5454-6768</idno>
              <affiliation ref="#struct-58157"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elizabeth</forename>
                <surname>Macintyre</surname>
              </persName>
              <idno type="idhal" notation="numeric">762165</idno>
              <idno type="halauthorid" notation="string">439080-762165</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0520-0493</idno>
              <affiliation ref="#struct-202761"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Marie-Claire</forename>
                <surname>Dagher</surname>
              </persName>
              <email type="md5">16a92a66fdebde7a6e37680303039cc5</email>
              <email type="domain">ibs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-07-31 16:01:40</date>
              <date type="whenModified">2026-04-03 13:58:15</date>
              <date type="whenReleased">2013-07-31 16:01:40</date>
              <date type="whenProduced">2013-07-05</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815171"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="140374">
                <persName>
                  <forename>Marie-Claire</forename>
                  <surname>Dagher</surname>
                </persName>
                <email type="md5">16a92a66fdebde7a6e37680303039cc5</email>
                <email type="domain">ibs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00849673</idno>
            <idno type="halUri">https://hal.science/hal-00849673</idno>
            <idno type="halBibtex">benabdelali:hal-00849673</idno>
            <idno type="halRefHtml">&lt;i&gt;Haematologica&lt;/i&gt;, 2013, 98 (11), pp.1711-1717 &lt;a target="_blank" href="https://dx.doi.org/10.3324/haematol.2013.086082"&gt;&amp;#x27E8;10.3324/haematol.2013.086082&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Haematologica, 2013, 98 (11), pp.1711-1717 &amp;#x27E8;10.3324/haematol.2013.086082&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-PARIS5" corresp="UNIV-PARIS">Université Paris Descartes (Paris 5)</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-THEREX" corresp="TIMC-IMAG">TheREx : Thérapeutique Recombinante Expérimentale</idno>
            <idno type="stamp" n="COMUE-NORMANDIE">Normandie Université</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="UNIROUEN">Université de Rouen Normandie</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SU-INF-2018" corresp="SORBONNE-UNIVERSITE">SORBONNE université &lt;2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="IBHGC" corresp="UNIV-PARIS13">Institut de Biomécanique Humaine Georges Charpak</idno>
            <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="ACT-R" corresp="UNIV-PARIS13">Act'R </idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The prognosis of CALM-AF10 positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Raouf</forename>
                    <surname>Ben Abdelali</surname>
                  </persName>
                  <idno type="halauthorid">685018-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vahid</forename>
                    <surname>Asnafi</surname>
                  </persName>
                  <idno type="halauthorid">220924-0</idno>
                  <affiliation ref="#struct-301664"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Petit</surname>
                  </persName>
                  <email type="md5">8b51dd807fe5c7514c6cc8a6ef824062</email>
                  <email type="domain">aphp.fr</email>
                  <idno type="idhal" notation="string">arnaudpetit</idno>
                  <idno type="idhal" notation="numeric">1903</idno>
                  <idno type="halauthorid" notation="string">14639-1903</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-1633-2011</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8363-1622</idno>
                  <idno type="IDREF">https://www.idref.fr/087801582</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/H-1633-2011</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Baptiste</forename>
                    <surname>Micol</surname>
                  </persName>
                  <idno type="halauthorid">726070-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Céline</forename>
                    <surname>Callens</surname>
                  </persName>
                  <idno type="halauthorid">433335-0</idno>
                  <affiliation ref="#struct-1288"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrick</forename>
                    <surname>Villarese</surname>
                  </persName>
                  <idno type="halauthorid">726071-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Delabesse</surname>
                  </persName>
                  <email type="md5">103e09ad32d1970bffff4833d3b433d4</email>
                  <email type="domain">iuct-oncopole.fr</email>
                  <idno type="idhal" notation="string">delabesse</idno>
                  <idno type="idhal" notation="numeric">1440591</idno>
                  <idno type="halauthorid" notation="string">726072-1440591</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0928-0753</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/I-5221-2016</idno>
                  <idno type="IDREF">https://www.idref.fr/104535237</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/I-5221-2016</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Oumedaly</forename>
                    <surname>Reman</surname>
                  </persName>
                  <idno type="halauthorid">440253-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stephane</forename>
                    <surname>Lepretre</surname>
                  </persName>
                  <idno type="halauthorid">685020-0</idno>
                  <affiliation ref="#struct-46229"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean Yves</forename>
                    <surname>Cahn</surname>
                  </persName>
                  <idno type="halauthorid">461385-0</idno>
                  <affiliation ref="#struct-388270"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gaelle</forename>
                    <surname>Guillerm</surname>
                  </persName>
                  <idno type="halauthorid">578108-0</idno>
                  <affiliation ref="#struct-165418"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Céline</forename>
                    <surname>Berthon</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">767888</idno>
                  <idno type="halauthorid" notation="string">690795-767888</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3474-2577</idno>
                  <affiliation ref="#struct-545691"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claude</forename>
                    <surname>Gardin</surname>
                  </persName>
                  <idno type="halauthorid">440254-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bernadette</forename>
                    <surname>Corront</surname>
                  </persName>
                  <idno type="halauthorid">440610-0</idno>
                  <affiliation ref="#struct-447517"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Thibaut</forename>
                    <surname>Leguay</surname>
                  </persName>
                  <idno type="halauthorid">685019-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Christine</forename>
                    <surname>Béné</surname>
                  </persName>
                  <email type="md5">1a9a93d17fa8a57c40f7eb287ac04f33</email>
                  <email type="domain">medecine.uhp-nancy.fr</email>
                  <idno type="idhal" notation="numeric">767851</idno>
                  <idno type="halauthorid" notation="string">392386-767851</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6569-7414</idno>
                  <idno type="IDREF">https://www.idref.fr/028595823</idno>
                  <affiliation ref="#struct-221698"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Norbert</forename>
                    <surname>Ifrah</surname>
                  </persName>
                  <email type="md5">5342c0438e9c786f1c3f15588e5818e1</email>
                  <email type="domain">chu-angers.fr</email>
                  <idno type="idhal" notation="numeric">1432242</idno>
                  <idno type="halauthorid" notation="string">440621-1432242</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3063-850X</idno>
                  <affiliation ref="#struct-99728"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guy</forename>
                    <surname>Leverger</surname>
                  </persName>
                  <idno type="halauthorid">153758-0</idno>
                  <affiliation ref="#struct-360410"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hervé</forename>
                    <surname>Dombret</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">759753</idno>
                  <idno type="halauthorid" notation="string">312283-759753</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5454-6768</idno>
                  <affiliation ref="#struct-58157"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elizabeth</forename>
                    <surname>Macintyre</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">762165</idno>
                  <idno type="halauthorid" notation="string">439080-762165</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0520-0493</idno>
                  <affiliation ref="#struct-202761"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">22186</idno>
                <idno type="issn">0390-6078</idno>
                <idno type="eissn">1592-8721</idno>
                <title level="j">Haematologica</title>
                <imprint>
                  <publisher>Ferrata Storti Foundation</publisher>
                  <biblScope unit="volume">98 </biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">1711-1717 </biblScope>
                  <date type="datePub">2013-07-05</date>
                  <date type="dateEpub">2013-07-05</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3324/haematol.2013.086082</idno>
              <idno type="pubmed">23831922</idno>
              <idno type="pubmedcentral">PMC3815171</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>: CALM-AF10 (also known as PICALM-MLLT10) is the commonest fusion protein in T-cell acute lymphoblastic leukemia, but its prognostic impact remains unclear. Molecular screening at diagnosis identified CALM-AF10 in 30/431 (7%) T-cell acute lymphoblastic leukemia patients aged 16 years and over and 15/234 (6%) in those aged up to 15 years. CALM-AF10 positive patients were predominantly (72%) surface (s)CD3/T-cell receptor negative in adults, but predominantly (67%) T-cell receptor positive in children. Amongst 22 adult CALM-AF10+ patients treated according to the LALA94/GRAALL03-05 protocols, the poor prognosis for event-free survival (p=0.0017) and overall survival (p=0.0014) was restricted to the 15 T-cell receptor negative cases. Amongst CALM-AF10+ T-cell receptor negative patients, 82% demonstrated an early T-cell precursor phenotype, reported to be of poor prognosis in pediatric T-cell acute lymphoblastic leukemia. Early T-cell precursor acute lymphoblastic leukemia corresponded to 22% of adult LALA94/GRAALL03-05 T-cell acute lymphoblastic leukemias, but had no prognostic impact per se. CALM-AF10 fusion within early T-cell precursor acute lymphoblastic leukemia (21%) did, however, identify a poor prognostic group for event-free survival (p=0.04). CALM-AF10 therefore identifies a poor prognostic group within sCD3/T-cell receptor negative adult T-cell acute lymphoblastic leukemias and is over-represented within early T-cell precursor acute lymphoblastic leukemias, where it identifies those likely to fail treatment. Its prognosis and overlap with early T-cell precursor acute lymphoblastic leukemia in pediatric T-cell acute lymphoblastic leukemia merits analysis. The clinical trial GRAALL was registered at Clinical Trials.gov number NCT00327678.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-301664" status="OLD">
          <idno type="IdRef">026404788</idno>
          <idno type="ISNI">0000 0001 2188 0914 </idno>
          <idno type="ROR">https://ror.org/0220k9r37</idno>
          <orgName>Université Paris Descartes - Paris 5</orgName>
          <orgName type="acronym">UPD5</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.parisdescartes.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1288" status="OLD">
          <idno type="RNSR">200412803D</idno>
          <orgName>Cytokines, hématopoïèse et réponse immune</orgName>
          <orgName type="acronym">CHRI</orgName>
          <date type="start">2004-01-01</date>
          <date type="end">2014-12-31</date>
          <desc>
            <address>
              <addrLine>Bâtiment Sèvres - Porte I 161 Rue de Sèvres 75743 PARIS CEDEX 15</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR 8147" active="#struct-301664" type="direct"/>
            <relation name="UMR 8147" active="#struct-303623" type="direct"/>
            <relation name="UMR8147" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-46229" status="OLD">
          <idno type="IdRef">185925588</idno>
          <idno type="RNSR">200816541Z</idno>
          <orgName>Groupe d'étude des proliférations lymphoïdes</orgName>
          <orgName type="acronym">GPL</orgName>
          <desc>
            <address>
              <addrLine>Centre Henri Becquerel 1, rue d'Amiens 76038 Rouen cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300318" type="direct"/>
            <relation active="#struct-455934" type="indirect"/>
            <relation name="U918" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388270" status="INCOMING">
          <orgName>TheREx</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-165418" status="INCOMING">
          <orgName>Service Hématologie</orgName>
          <desc>
            <address>
              <addrLine>Institut de Cancéro-hématologie - 2 Av Foch 29609 Brest Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-309659" type="direct"/>
            <relation active="#struct-356603" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-545691" status="OLD">
          <idno type="RNSR">200716489X</idno>
          <orgName>Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837</orgName>
          <orgName type="acronym">JPArc</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine Henri Warembourg - Pôle Recherche - 1 place de verdun 59045 Lille cedex.</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://crjpa.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-164505" type="direct"/>
            <relation name="U1172" active="#struct-303623" type="direct"/>
            <relation name="U837" active="#struct-374570" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-447517" status="VALID">
          <idno type="ROR">https://ror.org/03deam493</idno>
          <orgName>Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois]</orgName>
          <desc>
            <address>
              <addrLine>Chemin du Loup BP 1411074164 Saint-Julien-en-Genevois Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ch-annecygenevois.fr/fr</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-221698" status="OLD">
          <orgName>Relations Hôte-Environnement</orgName>
          <orgName type="acronym">RHEM</orgName>
          <date type="end">2012-12-31</date>
          <desc>
            <address>
              <addrLine>Université Henri Poincaré, Faculté de Médecine, av de la Forêt de Haye, 54500 Vandoeuvre-les-Nancy</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="EA4369" active="#struct-300291" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-99728" status="OLD">
          <orgName>Service d'hématologie clinique [Avicenne]</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-15786" type="direct"/>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300210" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-360410" status="VALID">
          <orgName>CHU Trousseau [APHP]</orgName>
          <desc>
            <address>
              <addrLine>26 Avenue du Dr Arnold Netter, 75012 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-armand-trousseau-1</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-58157" status="OLD">
          <orgName>Lymphocyte et cancer</orgName>
          <desc>
            <address>
              <addrLine>Hopital Saint-Louis, 1 Avenue Claude Vellefaux, 75010 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-301307" type="direct"/>
            <relation name="IFR105" active="#struct-300301" type="indirect"/>
            <relation name="IFR105" active="#struct-506757" type="indirect"/>
            <relation active="#struct-300068" type="indirect"/>
            <relation name="U462" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-202761" status="INCOMING">
          <orgName>Service hématologie</orgName>
          <desc>
            <address>
              <addrLine>149 rue de Sèvres 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-414766" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300318" status="VALID">
          <idno type="IdRef">026403919</idno>
          <idno type="ISNI">0000000121083034</idno>
          <idno type="ROR">https://ror.org/03nhjew95</idno>
          <orgName>Université de Rouen Normandie</orgName>
          <orgName type="acronym">UNIROUEN</orgName>
          <date type="start">1966-01-01</date>
          <desc>
            <address>
              <addrLine>1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-rouen.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-455934" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-455934" status="VALID">
          <idno type="IdRef">190906332</idno>
          <idno type="ISNI">0000000417859671 </idno>
          <idno type="ROR">https://ror.org/01k40cz91</idno>
          <orgName>Normandie Université</orgName>
          <orgName type="acronym">NU</orgName>
          <date type="start">2015-01-01</date>
          <desc>
            <address>
              <addrLine>Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.normandie-univ.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-309659" status="VALID">
          <orgName>Hôpital Morvan [Brest]</orgName>
          <desc>
            <address>
              <addrLine>2 Av Foch – 29609 Brest Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-356603" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Brest</orgName>
          <orgName type="acronym">CHRU Brest</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-164505" status="OLD">
          <idno type="IdRef">144876604</idno>
          <idno type="ROR">https://ror.org/03btvgn05</idno>
          <orgName>Université Lille Nord de France (COMUE)</orgName>
          <date type="start">2015-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>COMUE Communauté d'universités et établissements Lille-Nord-de-France - - 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d’Ascq Cedex - (A succédé au PRES Université de Lille Nord de France)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cue-lillenorddefrance.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-374570" status="VALID">
          <idno type="IdRef">223446556</idno>
          <idno type="ISNI">0000 0001 2242 6780</idno>
          <idno type="ROR">https://ror.org/02kzqn938</idno>
          <idno type="Wikidata">Q3551621</idno>
          <orgName>Université de Lille</orgName>
          <desc>
            <address>
              <addrLine>EPE Université de Lille. -- 42 rue Paul Duez, 59000 Lille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300291" status="OLD">
          <orgName>Université Henri Poincaré - Nancy 1</orgName>
          <orgName type="acronym">UHP</orgName>
          <date type="end">2011-12-31</date>
          <desc>
            <address>
              <addrLine>24-30 rue Lionnois, BP 60120, 54 003 NANCY cedex, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-15786" status="VALID">
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris 13</orgName>
          <orgName type="acronym">UP13</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris13.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300210" status="VALID">
          <idno type="IdRef">030351189</idno>
          <idno type="ROR">https://ror.org/03n6vs369</idno>
          <orgName>Hôpital Avicenne [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://chu93.aphp.fr/hopital-avicenne-bobigny/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-301307" status="OLD">
          <orgName>IFR de Saint-Louis - Institut universitaire d'hématologie</orgName>
          <orgName type="acronym">IFR105 - IUH</orgName>
          <date type="start">2000-01-01</date>
          <date type="end">2006-12-31</date>
          <desc>
            <address>
              <addrLine>1, avenue Claude Vellefaux, Centre Hayem 1er étage, Hôpital Saint-Louis 75010 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="IFR105" active="#struct-300301" type="direct"/>
            <relation name="IFR105" active="#struct-506757" type="direct"/>
            <relation active="#struct-300068" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300301" status="OLD">
          <idno type="IdRef">027542084</idno>
          <idno type="ISNI">0000000121514068</idno>
          <idno type="ROR">https://ror.org/02n7qrg46</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-506757" status="VALID">
          <idno type="IdRef">02869614X</idno>
          <idno type="ROR">https://ror.org/049am9t04</idno>
          <orgName>Hopital Saint-Louis [AP-HP]</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <addrLine>1 Avenue Claude Vellefaux, 75010 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopital-saintlouis.aphp.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-414766" status="VALID">
          <orgName>Hôpital Necker - Enfants Malades [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>149 Rue de Sèvres 75015 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://hopital-necker.aphp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>