<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00849281</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T07:33:14+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Gender differences in copper, zinc and selenium status in diabetic-free metabolic syndrome European population - the IMMIDIET study.</title>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Arnaud</surname>
              </persName>
              <idno type="halauthorid">94713-0</idno>
              <affiliation ref="#struct-455"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>de Lorgeril</surname>
              </persName>
              <email type="md5">bbff3ab0ad64c86a0ad80d45f1a942f5</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="idhal" notation="numeric">943451</idno>
              <idno type="halauthorid" notation="string">399953-943451</idno>
              <affiliation ref="#struct-388395"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">T.</forename>
                <surname>Akbaraly</surname>
              </persName>
              <idno type="halauthorid">725548-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Salen</surname>
              </persName>
              <idno type="halauthorid">399954-0</idno>
              <affiliation ref="#struct-388395"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Arnout</surname>
              </persName>
              <idno type="halauthorid">400213-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">F. P.</forename>
                <surname>Cappuccio</surname>
              </persName>
              <idno type="halauthorid">400214-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M. C. J. M.</forename>
                <surname>van Dongen</surname>
              </persName>
              <idno type="halauthorid">400215-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M. B.</forename>
                <surname>Donati</surname>
              </persName>
              <idno type="halauthorid">399948-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">V.</forename>
                <surname>Krogh</surname>
              </persName>
              <idno type="halauthorid">400216-0</idno>
              <affiliation ref="#struct-88703"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Siani</surname>
              </persName>
              <idno type="halauthorid">319765-0</idno>
              <affiliation ref="#struct-71177"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Iacoviello</surname>
              </persName>
              <idno type="halauthorid">399946-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Non</forename>
                <surname>Renseigné</surname>
              </persName>
              <idno type="halauthorid">345197-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Patricia</forename>
                <surname>Salen</surname>
              </persName>
              <email type="md5">5d809932810bd27b18002a40e073067e</email>
              <email type="domain">ujf-grenoble.fr.invalid</email>
            </editor>
            <funder ref="#projeurop-96194"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-07-30 15:31:44</date>
              <date type="whenModified">2025-09-27 20:04:03</date>
              <date type="whenReleased">2013-07-30 15:31:44</date>
              <date type="whenProduced">2012-06</date>
              <ref type="externalLink" target="https://api.istex.fr/ark:/67375/6H6-2BTMB1ZH-1/fulltext.pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="140373">
                <persName>
                  <forename>Patricia</forename>
                  <surname>Salen</surname>
                </persName>
                <email type="md5">5d809932810bd27b18002a40e073067e</email>
                <email type="domain">ujf-grenoble.fr.invalid</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00849281</idno>
            <idno type="halUri">https://hal.science/hal-00849281</idno>
            <idno type="halBibtex">arnaud:hal-00849281</idno>
            <idno type="halRefHtml">&lt;i&gt;Nutrition, Metabolism and Cardiovascular Diseases&lt;/i&gt;, 2012, 22 (6), pp.517-24. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.numecd.2010.09.005"&gt;&amp;#x27E8;10.1016/j.numecd.2010.09.005&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nutrition, Metabolism and Cardiovascular Diseases, 2012, 22 (6), pp.517-24. &amp;#x27E8;10.1016/j.numecd.2010.09.005&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-PRETA" corresp="TIMC-IMAG">PRETA : Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</idno>
            <idno type="stamp" n="CERMAV">CEntre de Recherches sur les MAcromolécules Végétales</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Gender differences in copper, zinc and selenium status in diabetic-free metabolic syndrome European population - the IMMIDIET study.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Arnaud</surname>
                  </persName>
                  <idno type="halauthorid">94713-0</idno>
                  <affiliation ref="#struct-455"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>de Lorgeril</surname>
                  </persName>
                  <email type="md5">bbff3ab0ad64c86a0ad80d45f1a942f5</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">943451</idno>
                  <idno type="halauthorid" notation="string">399953-943451</idno>
                  <affiliation ref="#struct-388395"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">T.</forename>
                    <surname>Akbaraly</surname>
                  </persName>
                  <idno type="halauthorid">725548-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Salen</surname>
                  </persName>
                  <idno type="halauthorid">399954-0</idno>
                  <affiliation ref="#struct-388395"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Arnout</surname>
                  </persName>
                  <idno type="halauthorid">400213-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">F. P.</forename>
                    <surname>Cappuccio</surname>
                  </persName>
                  <idno type="halauthorid">400214-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M. C. J. M.</forename>
                    <surname>van Dongen</surname>
                  </persName>
                  <idno type="halauthorid">400215-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M. B.</forename>
                    <surname>Donati</surname>
                  </persName>
                  <idno type="halauthorid">399948-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">V.</forename>
                    <surname>Krogh</surname>
                  </persName>
                  <idno type="halauthorid">400216-0</idno>
                  <affiliation ref="#struct-88703"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Siani</surname>
                  </persName>
                  <idno type="halauthorid">319765-0</idno>
                  <affiliation ref="#struct-71177"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Iacoviello</surname>
                  </persName>
                  <idno type="halauthorid">399946-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Non</forename>
                    <surname>Renseigné</surname>
                  </persName>
                  <idno type="halauthorid">345197-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">21554</idno>
                <idno type="issn">0939-4753</idno>
                <title level="j">Nutrition, Metabolism and Cardiovascular Diseases</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">22</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">517-24</biblScope>
                  <date type="datePub">2012-06</date>
                  <date type="dateEpub">2010-12-28</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.numecd.2010.09.005</idno>
              <idno type="pubmed">21193294</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Alcohol Drinking</classCode>
              <classCode scheme="mesh">Food Habits</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Hypertension</classCode>
              <classCode scheme="mesh">Italy</classCode>
              <classCode scheme="mesh">Lipids</classCode>
              <classCode scheme="mesh">London</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Metabolic Syndrome X</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Odds Ratio</classCode>
              <classCode scheme="mesh">Anthropometry</classCode>
              <classCode scheme="mesh">Questionnaires</classCode>
              <classCode scheme="mesh">Selenium</classCode>
              <classCode scheme="mesh">Sex Factors</classCode>
              <classCode scheme="mesh">Smoking</classCode>
              <classCode scheme="mesh">Zinc</classCode>
              <classCode scheme="mesh">Belgium</classCode>
              <classCode scheme="mesh">Copper</classCode>
              <classCode scheme="mesh">Cross-Sectional Studies</classCode>
              <classCode scheme="mesh">Diabetes Mellitus</classCode>
              <classCode scheme="mesh">Energy Intake</classCode>
              <classCode scheme="mesh">European Continental Ancestry Group</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="halDomain" n="sdv.aen">Life Sciences [q-bio]/Food and Nutrition</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>BACKGROUND AND AIMS: The European 'IMMIDIET' study was designed to evaluate the effect of genetic and dietary habit interactions on cardiovascular disease risk factors in non-diabetic subjects. Copper, zinc and selenium are involved in redox balance and modifications of their homeostasis could be associated with metabolic syndrome. Because few studies have dealt with trace element status in metabolic syndrome with conflicting results, we aimed at investigating the relationships between plasma copper, zinc and selenium concentrations and metabolic syndrome in the IMMIDIET population. METHODS AND RESULTS: Male-female couples born and living in Abruzzo, Italy (n = 271); Limburg, Belgium (n = 267), southwest part of London, England (n = 263) and 205 Italian-Belgian mixed couples living in Belgium were enrolled. Data on medical history, hypertension and blood lipid profile, medication use, smoking and alcohol habits, physical activity and socioeconomic status were collected using a standardised questionnaire. Anthropometric, blood pressure, glucose, insulin, lipid profile and copper, zinc and selenium measurements were performed. Participants were classified in two groups according to the presence of metabolic syndrome (Yes/No). Comparison between these two groups, performed separately in men and women, indicated no association in men whereas, in women, metabolic syndrome was associated with higher plasma selenium concentrations (odds ratio (OR) = 1.55(1.28-1.89)); this association remained significant after adjustment for age, group, social status, physical activity, energy intake, alcohol consumption, smoking and hormonal status (OR = 1.33 (1.06-1.67)). CONCLUSION: Our results indicate gender differences in the association between plasma selenium concentration and metabolic syndrome without diabetes and may suggest a sub-clinical deleterious effect of high selenium status in women.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-455" status="OLD">
          <idno type="IdRef">181532867</idno>
          <idno type="ISNI">0000000118823513</idno>
          <idno type="RNSR">196617508H</idno>
          <idno type="ROR">https://ror.org/0003ege03</idno>
          <orgName>Centre de Recherches sur les Macromolécules Végétales</orgName>
          <orgName type="acronym">CERMAV</orgName>
          <date type="start">1966-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>CS40700, 38041 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cermav.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UPR5301" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388395" status="OLD">
          <orgName>Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</orgName>
          <orgName type="acronym">TIMC-IMAG-PRETA</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr/preta</ref>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-88703" status="INCOMING">
          <orgName>Department of Preventive &amp; Predictive Medicine</orgName>
          <desc>
            <address>
              <addrLine>Nutritional Epidemiology Unit Milan</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-322166" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-71177" status="INCOMING">
          <orgName>Physics Department</orgName>
          <desc>
            <address>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-229915" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-322166" status="INCOMING">
          <orgName>Italian National Center Institute</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-229915" status="VALID">
          <idno type="IdRef">026430711</idno>
          <idno type="ROR">https://ror.org/02be6w209</idno>
          <orgName>Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]</orgName>
          <orgName type="acronym">UNIROMA</orgName>
          <date type="start">1303-01-01</date>
          <desc>
            <address>
              <addrLine>Piazzale Aldo Moro 5, 00185 Roma</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.uniroma1.it/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="europeanProject" xml:id="projeurop-96194" status="INCOMING">
          <desc>IMMIDIET</desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>