<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00843426</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-13T08:28:20+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Independent association of urinary F2-isoprostanes with survival in pulmonary arterial hypertension.</title>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Luc</forename>
                <surname>Cracowski</surname>
              </persName>
              <idno type="idhal" notation="numeric">756872</idno>
              <idno type="halauthorid" notation="string">159528-756872</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0787-1469</idno>
              <idno type="IDREF">https://www.idref.fr/085501980</idno>
              <affiliation ref="#struct-11960"/>
              <affiliation ref="#struct-2603"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Degano</surname>
              </persName>
              <idno type="halauthorid">578282-0</idno>
              <affiliation ref="#struct-27489"/>
              <affiliation ref="#struct-165585"/>
              <affiliation ref="#struct-165586"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Chabot</surname>
              </persName>
              <idno type="idhal" notation="numeric">768887</idno>
              <idno type="halauthorid" notation="string">721843-768887</idno>
              <idno type="IDREF">https://www.idref.fr/08552686X</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">José</forename>
                <surname>Labarère</surname>
              </persName>
              <idno type="halauthorid">250976-0</idno>
              <affiliation ref="#struct-400425"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Edzard</forename>
                <surname>Schwedhelm</surname>
              </persName>
              <idno type="halauthorid">539729-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Denis</forename>
                <surname>Monneret</surname>
              </persName>
              <idno type="halauthorid">608149-0</idno>
              <affiliation ref="#struct-11960"/>
              <affiliation ref="#struct-707"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luigi</forename>
                <surname>Iuliano</surname>
              </persName>
              <idno type="halauthorid">710211-0</idno>
              <affiliation ref="#struct-221643"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Carole</forename>
                <surname>Schwebel</surname>
              </persName>
              <email type="md5">bf7536186ab271a85d1e20fde1404584</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">1188361</idno>
              <idno type="halauthorid" notation="string">219935-1188361</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1837-7415</idno>
              <idno type="IDREF">https://www.idref.fr/060098635</idno>
              <affiliation ref="#struct-212677"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ari</forename>
                <surname>Chaouat</surname>
              </persName>
              <idno type="idhal" notation="numeric">761038</idno>
              <idno type="halauthorid" notation="string">386977-761038</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6056-202X</idno>
              <idno type="IDREF">https://www.idref.fr/060830328</idno>
              <affiliation ref="#struct-245658"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Martine</forename>
                <surname>Reynaud-Gaubert</surname>
              </persName>
              <idno type="halauthorid">576920-0</idno>
              <affiliation ref="#struct-173727"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Patrice</forename>
                <surname>Faure</surname>
              </persName>
              <email type="md5">c212aaee5aa64a55e21ce0716c4ec0c0</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">870588</idno>
              <idno type="halauthorid" notation="string">23659-870588</idno>
              <idno type="IDREF">https://www.idref.fr/060963190</idno>
              <idno type="ISNI">http://isni.org/isni/0000000441600424</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0963-6932</idno>
              <idno type="VIAF">https://viaf.org/viaf/216064054</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-7139-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/EYK-7429-2022</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-7139-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/EYK-7429-2022</idno>
              <affiliation ref="#struct-11960"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Renke</forename>
                <surname>Maas</surname>
              </persName>
              <idno type="halauthorid">403993-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Charles</forename>
                <surname>Renversez</surname>
              </persName>
              <idno type="halauthorid">204418-0</idno>
              <affiliation ref="#struct-34732"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Cracowski</surname>
              </persName>
              <idno type="idhal" notation="numeric">756872</idno>
              <idno type="halauthorid" notation="string">362345-756872</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0787-1469</idno>
              <idno type="IDREF">https://www.idref.fr/085501980</idno>
              <affiliation ref="#struct-11960"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Sitbon</surname>
              </persName>
              <email type="md5">576ed2fc8c15f672c0e67a4a6d7699df</email>
              <email type="domain">abc.aphp.fr</email>
              <idno type="idhal" notation="numeric">763553</idno>
              <idno type="halauthorid" notation="string">515673-763553</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1942-1951</idno>
              <idno type="IDREF">https://www.idref.fr/081152221</idno>
              <affiliation ref="#struct-120468"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Azzedine</forename>
                <surname>Yaïci</surname>
              </persName>
              <idno type="halauthorid">572095-0</idno>
              <affiliation ref="#struct-120468"/>
              <affiliation ref="#struct-18276"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gerald</forename>
                <surname>Simonneau</surname>
              </persName>
              <idno type="halauthorid">476366-0</idno>
              <affiliation ref="#struct-120468"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marc</forename>
                <surname>Humbert</surname>
              </persName>
              <email type="md5">c96ebb0e3ab5bf9eeaf5a83544944f85</email>
              <email type="domain">abc.aphp.fr</email>
              <idno type="idhal" notation="numeric">1113540</idno>
              <idno type="halauthorid" notation="string">158428-1113540</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0703-2892</idno>
              <idno type="IDREF">https://www.idref.fr/071559426</idno>
              <affiliation ref="#struct-120468"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jose</forename>
                <surname>Labarere</surname>
              </persName>
              <email type="md5">1a8f7ccb5bd17297b82ff42238a5b967</email>
              <email type="domain">chu-grenoble.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-07-11 12:32:28</date>
              <date type="whenModified">2026-05-13 03:07:26</date>
              <date type="whenReleased">2013-07-11 12:32:28</date>
              <date type="whenProduced">2012-10</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="123487">
                <persName>
                  <forename>Jose</forename>
                  <surname>Labarere</surname>
                </persName>
                <email type="md5">1a8f7ccb5bd17297b82ff42238a5b967</email>
                <email type="domain">chu-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00843426</idno>
            <idno type="halUri">https://hal.science/hal-00843426</idno>
            <idno type="halBibtex">cracowski:hal-00843426</idno>
            <idno type="halRefHtml">&lt;i&gt;Chest&lt;/i&gt;, 2012, 142 (4), pp.869-76. &lt;a target="_blank" href="https://dx.doi.org/10.1378/chest.11-1267"&gt;&amp;#x27E8;10.1378/chest.11-1267&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Chest, 2012, 142 (4), pp.869-76. &amp;#x27E8;10.1378/chest.11-1267&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-ST-ETIENNE">Université Jean Monnet - Saint-Etienne</idno>
            <idno type="stamp" n="UNIV-TLSE3">Université de Toulouse</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="UNIV-PSUD">Université Paris Sud - Paris XI</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-BCM" corresp="TIMC-IMAG">BCM : Biologie Computationnelle et Mathématique</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UNIV-PSUD-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris Sud pour Paris Saclay</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="GS-HEALTH-DRUG-SCIENCES">Graduate School Health and Drug Sciences</idno>
            <idno type="stamp" n="UNIV-UT3">Université Toulouse 3</idno>
            <idno type="stamp" n="UT3-INP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="UT3-TOULOUSEINP">Université de Toulouse / Toulouse INP</idno>
            <idno type="stamp" n="HPPIT">Hypertension pulmonaire : physiopathologie et innovation thérapeutique</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Independent association of urinary F2-isoprostanes with survival in pulmonary arterial hypertension.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Luc</forename>
                    <surname>Cracowski</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">756872</idno>
                  <idno type="halauthorid" notation="string">159528-756872</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0787-1469</idno>
                  <idno type="IDREF">https://www.idref.fr/085501980</idno>
                  <affiliation ref="#struct-11960"/>
                  <affiliation ref="#struct-2603"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Degano</surname>
                  </persName>
                  <idno type="halauthorid">578282-0</idno>
                  <affiliation ref="#struct-27489"/>
                  <affiliation ref="#struct-165585"/>
                  <affiliation ref="#struct-165586"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Chabot</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">768887</idno>
                  <idno type="halauthorid" notation="string">721843-768887</idno>
                  <idno type="IDREF">https://www.idref.fr/08552686X</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">José</forename>
                    <surname>Labarère</surname>
                  </persName>
                  <idno type="halauthorid">250976-0</idno>
                  <affiliation ref="#struct-400425"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Edzard</forename>
                    <surname>Schwedhelm</surname>
                  </persName>
                  <idno type="halauthorid">539729-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Denis</forename>
                    <surname>Monneret</surname>
                  </persName>
                  <idno type="halauthorid">608149-0</idno>
                  <affiliation ref="#struct-11960"/>
                  <affiliation ref="#struct-707"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luigi</forename>
                    <surname>Iuliano</surname>
                  </persName>
                  <idno type="halauthorid">710211-0</idno>
                  <affiliation ref="#struct-221643"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Carole</forename>
                    <surname>Schwebel</surname>
                  </persName>
                  <email type="md5">bf7536186ab271a85d1e20fde1404584</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">1188361</idno>
                  <idno type="halauthorid" notation="string">219935-1188361</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1837-7415</idno>
                  <idno type="IDREF">https://www.idref.fr/060098635</idno>
                  <affiliation ref="#struct-212677"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ari</forename>
                    <surname>Chaouat</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">761038</idno>
                  <idno type="halauthorid" notation="string">386977-761038</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6056-202X</idno>
                  <idno type="IDREF">https://www.idref.fr/060830328</idno>
                  <affiliation ref="#struct-245658"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Martine</forename>
                    <surname>Reynaud-Gaubert</surname>
                  </persName>
                  <idno type="halauthorid">576920-0</idno>
                  <affiliation ref="#struct-173727"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Patrice</forename>
                    <surname>Faure</surname>
                  </persName>
                  <email type="md5">c212aaee5aa64a55e21ce0716c4ec0c0</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">870588</idno>
                  <idno type="halauthorid" notation="string">23659-870588</idno>
                  <idno type="IDREF">https://www.idref.fr/060963190</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000441600424</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0963-6932</idno>
                  <idno type="VIAF">https://viaf.org/viaf/216064054</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-7139-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/EYK-7429-2022</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-7139-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/EYK-7429-2022</idno>
                  <affiliation ref="#struct-11960"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Renke</forename>
                    <surname>Maas</surname>
                  </persName>
                  <idno type="halauthorid">403993-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Charles</forename>
                    <surname>Renversez</surname>
                  </persName>
                  <idno type="halauthorid">204418-0</idno>
                  <affiliation ref="#struct-34732"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Cracowski</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">756872</idno>
                  <idno type="halauthorid" notation="string">362345-756872</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0787-1469</idno>
                  <idno type="IDREF">https://www.idref.fr/085501980</idno>
                  <affiliation ref="#struct-11960"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Sitbon</surname>
                  </persName>
                  <email type="md5">576ed2fc8c15f672c0e67a4a6d7699df</email>
                  <email type="domain">abc.aphp.fr</email>
                  <idno type="idhal" notation="numeric">763553</idno>
                  <idno type="halauthorid" notation="string">515673-763553</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1942-1951</idno>
                  <idno type="IDREF">https://www.idref.fr/081152221</idno>
                  <affiliation ref="#struct-120468"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Azzedine</forename>
                    <surname>Yaïci</surname>
                  </persName>
                  <idno type="halauthorid">572095-0</idno>
                  <affiliation ref="#struct-120468"/>
                  <affiliation ref="#struct-18276"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gerald</forename>
                    <surname>Simonneau</surname>
                  </persName>
                  <idno type="halauthorid">476366-0</idno>
                  <affiliation ref="#struct-120468"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marc</forename>
                    <surname>Humbert</surname>
                  </persName>
                  <email type="md5">c96ebb0e3ab5bf9eeaf5a83544944f85</email>
                  <email type="domain">abc.aphp.fr</email>
                  <idno type="idhal" notation="numeric">1113540</idno>
                  <idno type="halauthorid" notation="string">158428-1113540</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0703-2892</idno>
                  <idno type="IDREF">https://www.idref.fr/071559426</idno>
                  <affiliation ref="#struct-120468"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">11648</idno>
                <idno type="issn">0012-3692</idno>
                <idno type="eissn">1931-3543</idno>
                <title level="j">Chest</title>
                <imprint>
                  <publisher>American College of Chest Physicians</publisher>
                  <biblScope unit="volume">142</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">869-76</biblScope>
                  <date type="datePub">2012-10</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1378/chest.11-1267</idno>
              <idno type="pubmed">22406961</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Biological Markers</classCode>
              <classCode scheme="mesh">Cause of Death</classCode>
              <classCode scheme="mesh">Kaplan-Meier Estimate</classCode>
              <classCode scheme="mesh">Lipid Peroxidation</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Prognosis</classCode>
              <classCode scheme="mesh">Retrospective Studies</classCode>
              <classCode scheme="mesh">Risk Factors</classCode>
              <classCode scheme="mesh">Survival Rate</classCode>
              <classCode scheme="mesh">Enzyme-Linked Immunosorbent Assay</classCode>
              <classCode scheme="mesh">F2-Isoprostanes</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Follow-Up Studies</classCode>
              <classCode scheme="mesh">France</classCode>
              <classCode scheme="mesh">Gas Chromatography-Mass Spectrometry</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Hypertension, Pulmonary</classCode>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>OBJECTIVES: Within the past decade, biochemical markers have emerged as attractive tools to assess pulmonary arterial hypertension (PAH) prognosis, being noninvasive and easily repeatable.The objective of this study was to determine whether biomarkers measured at initial diagnostic right-sided heart catheterization predict 3-year all-cause mortality for incident cases of PAH independently of clinical and hemodynamic parameters. METHODS: Patients with incident PAH were enrolled between December 2003 and April 2006 in six centers from the French Network on Pulmonary Hypertension and followed for 3 years.Venous blood samples were taken during right-sided heart catheterization, and analyses were centralized. RESULTS: Among 110 enrolled patients, 11 underwent lung or heart/lung transplantation, and 27 died during follow-up. The Kaplan-Meier estimates of survival were 91%, 78%, and 75% at 1, 2, and 3 years, respectively. Plasma big endothelin-1 (hazard ratio [HR] per 1-SD increase, 1.48; 95% CI,1.14-1.92), serum troponin T . 0.01 mg/L (HR, 2.35; 95% CI, 1.05-5.29), and urinary F 2 -isoprostanes(15-F2t -isoprostane) (HR per 1-SD increase, 1.76; 95% CI, 1.31-2.36) were associated with increased unadjusted hazard of death. In multivariate analysis adjusting for patient characteristics, the level of urinary F 2 -isoprostanes was the only biomarker that remained independently associated with increased hazard of death (HR per 1-SD increase, 1.82; 95% CI, 1.28-2.60). CONCLUSIONS: This study shows that levels of urinary F 2 -isoprostane, a biomarker of lipid peroxidation,quantified at initial diagnostic right-sided heart catheterization are independently associated with mortality in a cohort of patients with incident PAH.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-11960" status="OLD">
          <idno type="IdRef">18493902X</idno>
          <idno type="RNSR">201119418N</idno>
          <orgName>Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire</orgName>
          <orgName type="acronym">HP2</orgName>
          <date type="start">2002-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Facultés de médecine et de pharmacie Domaine de la merci 38706 LA TRONCHE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://hp2.univ-grenoble-alpes.fr/accueil</ref>
          </desc>
          <listRelation>
            <relation name="EA3745 / ERI17" active="#struct-51016" type="direct"/>
            <relation name="U1042" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2603" status="INCOMING">
          <orgName>CIC - Grenoble</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire LYON 38043 GRENOBLE CEDEX 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lyon.inserm.fr/cic-grenoble/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation name="CIC3" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-27489" status="OLD">
          <orgName>Institut de médecine moléculaire de Rangueil</orgName>
          <orgName type="acronym">I2MR</orgName>
          <desc>
            <address>
              <addrLine>Institut Louis Bugnard 1, avenue Jean Poulhes BP 84225 31432 TOULOUSE CEDEX 4</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation active="#struct-301493" type="direct"/>
            <relation name="U858" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-165585" status="INCOMING">
          <orgName>Physiopathologie cardiovasculaire et prévention</orgName>
          <desc>
            <address>
              <addrLine>25030 Besançon</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-458810" type="direct"/>
            <relation active="#struct-426438" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-165586" status="INCOMING">
          <orgName>Département de physiologie</orgName>
          <desc>
            <address>
              <addrLine>25030 Besançon</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300165" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-400425" status="INCOMING">
          <orgName>BCM</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-257328" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-221643" status="INCOMING">
          <orgName>Department of Medico-Surgical Sciences &amp; Biotechnologies</orgName>
          <desc>
            <address>
              <addrLine>Latina</addrLine>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-229915" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-212677" status="VALID">
          <orgName>Service de Réanimation Médicale [Grenoble]</orgName>
          <desc>
            <address>
              <addrLine>Pôle de Médecine Aiguë et Communautaire - boulevard de la chantourne - BP 217 - 38043 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-grenoble.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-257328" type="direct"/>
            <relation active="#struct-300199" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-245658" status="VALID">
          <orgName>Service des Maladies Infectieuses et Tropicales [CHRU Nancy]</orgName>
          <desc>
            <address>
              <addrLine>Vandœuvre-lès-Nancy</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-173727" status="INCOMING">
          <orgName>Service de chirurgie thoracique</orgName>
          <desc>
            <address>
              <addrLine>Marseille</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-51335" type="direct"/>
            <relation active="#struct-1327915" type="indirect"/>
            <relation active="#struct-300073" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-34732" status="VALID">
          <orgName>Département de biologie intégrée</orgName>
          <desc>
            <address>
              <addrLine>Grenoble</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-257328" type="direct"/>
            <relation active="#struct-300199" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-120468" status="OLD">
          <orgName>Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique</orgName>
          <orgName type="acronym">HPPIT</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>133 avenue de la Résistance, 92350 Le Plessis-Robinson</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.htapfrance.com/je-m-informe/voies_de_recherche.asp?rubrique=2</ref>
          </desc>
          <listRelation>
            <relation active="#struct-92966" type="direct"/>
            <relation active="#struct-217059" type="direct"/>
            <relation name="U999" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-18276" status="VALID">
          <orgName>Service de pneumologie [Béclère]</orgName>
          <desc>
            <address>
              <addrLine>157 rue de la Porte-de-Trivaux 92140 Clamart</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-300141" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301493" status="OLD">
          <orgName> Institut Fédératif de Recherche Bio-médicale Institution</orgName>
          <orgName type="acronym">IFR150</orgName>
          <desc>
            <address>
              <addrLine>Place du Docteur Baylac , TSA 40031 , 31059 Toulouse cedex 9</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-458810" status="VALID">
          <idno type="IdRef">026403188</idno>
          <idno type="ISNI">0000000121883779</idno>
          <idno type="ROR">https://ror.org/03pcc9z86</idno>
          <orgName>Université Marie et Louis Pasteur</orgName>
          <orgName type="acronym">UMLP</orgName>
          <desc>
            <address>
              <addrLine>1 rue Goudimel25030 Besançon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.umlp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-426438" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-426438" status="VALID">
          <idno type="IdRef">200716271</idno>
          <idno type="ISNI">0000 0004 4910 6615</idno>
          <idno type="ROR">https://ror.org/02dn7x778</idno>
          <orgName>Université Bourgogne Franche-Comté [COMUE]</orgName>
          <orgName type="acronym">UBFC</orgName>
          <date type="start">2015-04-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>32, avenue de l’observatoire25000 BESANCON</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ubfc.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300165" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Besançon</orgName>
          <orgName type="acronym">CHRU Besançon</orgName>
          <desc>
            <address>
              <addrLine>3, boulevard A. Fleming - 25030 Besançon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-besancon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-229915" status="VALID">
          <idno type="IdRef">026430711</idno>
          <idno type="ROR">https://ror.org/02be6w209</idno>
          <orgName>Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]</orgName>
          <orgName type="acronym">UNIROMA</orgName>
          <date type="start">1303-01-01</date>
          <desc>
            <address>
              <addrLine>Piazzale Aldo Moro 5, 00185 Roma</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.uniroma1.it/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300199" status="VALID">
          <orgName>Hôpital Michallon</orgName>
          <desc>
            <address>
              <addrLine>CHU Grenoble-Alpes</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300157" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Nancy</orgName>
          <orgName type="acronym">CHRU Nancy</orgName>
          <desc>
            <address>
              <addrLine>Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXHôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 NancyHôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-NancyMaternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-51335" status="VALID">
          <idno type="IdRef">250789094</idno>
          <idno type="ROR">https://ror.org/04pn6vp43</idno>
          <orgName>Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]</orgName>
          <orgName type="acronym">CHU ST-E</orgName>
          <date type="start">1972-10-30</date>
          <desc>
            <address>
              <addrLine>42055 Saint Etienne cedex 2</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-st-etienne.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1327915" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-1327915" status="VALID">
          <idno type="IdRef">285395831</idno>
          <orgName>Université Jean Monnet (EPSCPE)</orgName>
          <orgName type="acronym">UJM EPE</orgName>
          <date type="start">2025-01-01</date>
          <desc>
            <address>
              <addrLine>10 rue Tréfilerie42100 Saint-Etienne</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-st-etienne.fr/fr/index.html</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300073" status="VALID">
          <idno type="ROR">https://ror.org/002cp4060</idno>
          <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
          <orgName type="acronym">APHM</orgName>
          <desc>
            <address>
              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92966" status="OLD">
          <idno type="ROR">https://ror.org/028rypz17</idno>
          <orgName>Université Paris-Sud - Paris 11</orgName>
          <orgName type="acronym">UP11</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-psud.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217059" status="OLD">
          <idno type="ROR">https://ror.org/029gxzx35</idno>
          <orgName>Centre Chirurgical Marie Lannelongue</orgName>
          <orgName type="acronym">CCML</orgName>
          <desc>
            <address>
              <addrLine>133 avenue de la Résistance - 92350 Le Plessis Robinson Plessis Robinson</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ccml.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300141" status="VALID">
          <idno type="ROR">https://ror.org/04sb8a726</idno>
          <orgName>AP-HP - Hôpital Antoine Béclère [Clamart]</orgName>
          <date type="start">1970-01-01</date>
          <desc>
            <address>
              <addrLine>157, rue de la Porte de Trivaux 92140 Clamart</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://hopital-antoine-beclere.aphp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>