Synchrotron Radiation Micro-Computed Tomography as a new method to detect iron oxide nanoparticles in the brain
Résumé
MRI coupled with the injection of Ultrasmall particles of iron oxide (USPIO) has been successfully applied for pre-clinical and clinical studies of cerebral inflammation following stroke. Current limitations of this approach are represented by the difficulty of interpreting MR signal changes in terms of exact localization and quantification of USPIO. To overcome this limitation, Synchrotron Radiation phase micro computerized tomography (SR-PCT) was proposed as a new method to visualize USPIO distribution into the whole brains of mice.