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Article Dans Une Revue Journal of Polymer Science Année : 2013

Synthesis of Homopolypeptides with PPII Structure

Résumé

Polyprolines are attractive polymers because of their folding property into polyproline II (PPII) structure, their significance in protein/protein interactions, and their potential as new therapeutic targets. Silaproline (Sip) is an analogue of proline, which exhibits similar conformational properties. The presence of dimethylsilyl group confers to Sip a higher lipophilicity as well as an improved resistance to biodegradation. Enantiomerically pure Sip was available in gram quantities from resolution of the enantiomers by chiral high performance liquid chromatography. This study describes the first synthesis of Sip N-carboxyanhydride (NCA) and shows preliminary results on comparison of polymerization of (L)ProNCA and (D)Sip-NCA to obtain homopolypeptides with PPII structure, polyproline, and polysilaproline polymers.

Dates et versions

hal-00838581 , version 1 (26-06-2013)

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Charlotte Martin, Aurélien Lebrun, Jean Martinez, Florine Cavelier. Synthesis of Homopolypeptides with PPII Structure. Journal of Polymer Science, 2013, 51, pp.3103-3109. ⟨10.1002/pola.26705⟩. ⟨hal-00838581⟩
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